Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter

Jiashen Wei; Wai Chye Cheong; Mo Huang Li; Jackie Y. Ying

Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter

Jiashen Wei
, Wai Chye Cheong
, Mo Huang Li
, Jackie Y. Ying

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Circulating tumor cells (CTCs) are rare in peripheral blood from cancer patients, but probably result in cancer metastasis. Herein we present a novel device to isolate the CTCs for effectively enumerating the CTCs from blood samples without sample dilution or antibody conjugation. The device utilizes the distinct morphology and size difference of cancer cells and leukocytes to extract the CTCs. The device contains densely packed pore arrays with optimized pore diameter, effectively retaining > 94% of various cancer cells.

Original language	English
Title of host publication	Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	1764-1766
Number of pages	3
ISBN (Print)	9780979806421
State	Published - 2009
Externally published	Yes
Event	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of Duration: 1 Nov 2009 → 5 Nov 2009

Publication series

Name	Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference	13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/Territory	Korea, Republic of
City	Jeju
Period	1/11/09 → 5/11/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer diagnostics
Circulating tumor cells isolation
Silicon microsieve

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Wei, J., Cheong, W. C., Li, M. H., & Ying, J. Y. (2009). Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1764-1766). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Wei, Jiashen ; Cheong, Wai Chye ; Li, Mo Huang et al. / Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 1764-1766 (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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title = "Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter",

abstract = "Circulating tumor cells (CTCs) are rare in peripheral blood from cancer patients, but probably result in cancer metastasis. Herein we present a novel device to isolate the CTCs for effectively enumerating the CTCs from blood samples without sample dilution or antibody conjugation. The device utilizes the distinct morphology and size difference of cancer cells and leukocytes to extract the CTCs. The device contains densely packed pore arrays with optimized pore diameter, effectively retaining > 94\% of various cancer cells.",

keywords = "Cancer diagnostics, Circulating tumor cells isolation, Silicon microsieve",

author = "Jiashen Wei and Cheong, \{Wai Chye\} and Li, \{Mo Huang\} and Ying, \{Jackie Y.\}",

year = "2009",

language = "English",

isbn = "9780979806421",

series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

pages = "1764--1766",

booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",

}

Wei, J, Cheong, WC, Li, MH & Ying, JY 2009, Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1764-1766, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of, 1/11/09.

Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter. / Wei, Jiashen; Cheong, Wai Chye; Li, Mo Huang et al.
Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 1764-1766 (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter

AU - Wei, Jiashen

AU - Cheong, Wai Chye

AU - Li, Mo Huang

AU - Ying, Jackie Y.

PY - 2009

Y1 - 2009

N2 - Circulating tumor cells (CTCs) are rare in peripheral blood from cancer patients, but probably result in cancer metastasis. Herein we present a novel device to isolate the CTCs for effectively enumerating the CTCs from blood samples without sample dilution or antibody conjugation. The device utilizes the distinct morphology and size difference of cancer cells and leukocytes to extract the CTCs. The device contains densely packed pore arrays with optimized pore diameter, effectively retaining > 94% of various cancer cells.

AB - Circulating tumor cells (CTCs) are rare in peripheral blood from cancer patients, but probably result in cancer metastasis. Herein we present a novel device to isolate the CTCs for effectively enumerating the CTCs from blood samples without sample dilution or antibody conjugation. The device utilizes the distinct morphology and size difference of cancer cells and leukocytes to extract the CTCs. The device contains densely packed pore arrays with optimized pore diameter, effectively retaining > 94% of various cancer cells.

KW - Cancer diagnostics

KW - Circulating tumor cells isolation

KW - Silicon microsieve

UR - https://www.scopus.com/pages/publications/84901796635

M3 - Conference contribution

AN - SCOPUS:84901796635

SN - 9780979806421

T3 - Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 1764

EP - 1766

BT - Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009

Y2 - 1 November 2009 through 5 November 2009

ER -

Wei J, Cheong WC, Li MH, Ying JY. Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 1764-1766. (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Highly efficient circulating tumor cells isolation using silicon microsieve with controlled pore diameter

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

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