Abstract
Methyl-5-benzoyl-2-benzimidazole carbamate (mebendazole) is a drug used as an anthelmintic. A high performance liquid chromatography method has been developed in this study to determine mebendazole and its degradation product in the pharmaceutical dosage forms (tablets and suspension). The expected major degradation product of mebendazole in the dosage forms has been prepared, and identified as 2-amino-5-benzoylbenzimidazole. The proposed HPLC assay was found to be selective, accurate (% recoveries were in the range of 99.9-100.9) for both, mebendazole and the degradation product, repeatable and reproducible (replicate measurements for short and long term measurements showed % RSD of ≤1.4). The methodology could be considered as a stability indicating method for mebendazole in pharmaceutical dosage forms.
| Original language | English |
|---|---|
| Pages (from-to) | 1089-1097 |
| Number of pages | 9 |
| Journal | Talanta |
| Volume | 50 |
| Issue number | 5 |
| DOIs | |
| State | Published - Dec 1999 |
Bibliographical note
Funding Information:JPM and KFUPM are thanked for the support of this research project.
Keywords
- Degradation
- HPLC
- Mebendazole
- Pharmaceutical dosage forms
ASJC Scopus subject areas
- Analytical Chemistry
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