Heteroatom-Doped Carbon Nanoparticle-Ionic Liquid Composites as Electrochemical Sensors for Uric Acid

Yasir Abbas; Shafqat Ali; Majid Basharat; Wenqi Zou; Fan Yang; Wei Liu; Shuangkun Zhang; Zhanpeng Wu; Naeem Akhtar; Dezhen Wu

doi:10.1021/acsanm.0c02466

Heteroatom-Doped Carbon Nanoparticle-Ionic Liquid Composites as Electrochemical Sensors for Uric Acid

Yasir Abbas, Shafqat Ali, Majid Basharat, Wenqi Zou, Fan Yang, Wei Liu, Shuangkun Zhang, Zhanpeng Wu^*, Naeem Akhtar^*, Dezhen Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

We reported the fabrication of an electrochemical sensor for uric acid (UA) monitoring using metal-free electrode based on heteroatoms (S, N, P, and O) doped carbon (HADC) nanoparticles, derived from polyphosphazene, synthesized via precipitation polymerization reaction between hexachlorocyclotriphosphazene (HCCP) and 1,4-dithiane-2,5-diol (DD) under sonication irradiations at 40 °C, following its modification with benzimidazolium-1-acetate ionic liquid (BIL). The developed HADC-BIL electrode showed a highly sensitive and selective response toward UA even in the presence of highly electroactive interferences such as ascorbic acid (AA), dopamine (DA), glucose (Glu), and hydrogen peroxide (H2O2). Our results demonstrated that the as-fabricated HADC-BIL electrode allows us to detect UA over a linear range of 2-1050 μM with a detection limit of 1.27 μM. Further, we were able to monitor the amount of UA level in the blood of a gout patient using the developed HADC-BIL electrode, which ensures the effectiveness of the developed sensor for the sensitive and selective detection of UA from real samples.

Original language	English
Pages (from-to)	11383-11390
Number of pages	8
Journal	ACS Applied Nano Materials
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acsanm.0c02466
State	Published - 25 Nov 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 American Chemical Society.

Keywords

UA sensor
carbons
intrinsic doping
ionic liquid
polyphosphazene

ASJC Scopus subject areas

General Materials Science

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10.1021/acsanm.0c02466

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title = "Heteroatom-Doped Carbon Nanoparticle-Ionic Liquid Composites as Electrochemical Sensors for Uric Acid",

abstract = "We reported the fabrication of an electrochemical sensor for uric acid (UA) monitoring using metal-free electrode based on heteroatoms (S, N, P, and O) doped carbon (HADC) nanoparticles, derived from polyphosphazene, synthesized via precipitation polymerization reaction between hexachlorocyclotriphosphazene (HCCP) and 1,4-dithiane-2,5-diol (DD) under sonication irradiations at 40 °C, following its modification with benzimidazolium-1-acetate ionic liquid (BIL). The developed HADC-BIL electrode showed a highly sensitive and selective response toward UA even in the presence of highly electroactive interferences such as ascorbic acid (AA), dopamine (DA), glucose (Glu), and hydrogen peroxide (H2O2). Our results demonstrated that the as-fabricated HADC-BIL electrode allows us to detect UA over a linear range of 2-1050 μM with a detection limit of 1.27 μM. Further, we were able to monitor the amount of UA level in the blood of a gout patient using the developed HADC-BIL electrode, which ensures the effectiveness of the developed sensor for the sensitive and selective detection of UA from real samples.",

keywords = "UA sensor, carbons, intrinsic doping, ionic liquid, polyphosphazene",

author = "Yasir Abbas and Shafqat Ali and Majid Basharat and Wenqi Zou and Fan Yang and Wei Liu and Shuangkun Zhang and Zhanpeng Wu and Naeem Akhtar and Dezhen Wu",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2020",

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day = "25",

doi = "10.1021/acsanm.0c02466",

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T1 - Heteroatom-Doped Carbon Nanoparticle-Ionic Liquid Composites as Electrochemical Sensors for Uric Acid

AU - Abbas, Yasir

AU - Ali, Shafqat

AU - Basharat, Majid

AU - Zou, Wenqi

AU - Yang, Fan

AU - Liu, Wei

AU - Zhang, Shuangkun

AU - Wu, Zhanpeng

AU - Akhtar, Naeem

AU - Wu, Dezhen

PY - 2020/11/25

Y1 - 2020/11/25

N2 - We reported the fabrication of an electrochemical sensor for uric acid (UA) monitoring using metal-free electrode based on heteroatoms (S, N, P, and O) doped carbon (HADC) nanoparticles, derived from polyphosphazene, synthesized via precipitation polymerization reaction between hexachlorocyclotriphosphazene (HCCP) and 1,4-dithiane-2,5-diol (DD) under sonication irradiations at 40 °C, following its modification with benzimidazolium-1-acetate ionic liquid (BIL). The developed HADC-BIL electrode showed a highly sensitive and selective response toward UA even in the presence of highly electroactive interferences such as ascorbic acid (AA), dopamine (DA), glucose (Glu), and hydrogen peroxide (H2O2). Our results demonstrated that the as-fabricated HADC-BIL electrode allows us to detect UA over a linear range of 2-1050 μM with a detection limit of 1.27 μM. Further, we were able to monitor the amount of UA level in the blood of a gout patient using the developed HADC-BIL electrode, which ensures the effectiveness of the developed sensor for the sensitive and selective detection of UA from real samples.

AB - We reported the fabrication of an electrochemical sensor for uric acid (UA) monitoring using metal-free electrode based on heteroatoms (S, N, P, and O) doped carbon (HADC) nanoparticles, derived from polyphosphazene, synthesized via precipitation polymerization reaction between hexachlorocyclotriphosphazene (HCCP) and 1,4-dithiane-2,5-diol (DD) under sonication irradiations at 40 °C, following its modification with benzimidazolium-1-acetate ionic liquid (BIL). The developed HADC-BIL electrode showed a highly sensitive and selective response toward UA even in the presence of highly electroactive interferences such as ascorbic acid (AA), dopamine (DA), glucose (Glu), and hydrogen peroxide (H2O2). Our results demonstrated that the as-fabricated HADC-BIL electrode allows us to detect UA over a linear range of 2-1050 μM with a detection limit of 1.27 μM. Further, we were able to monitor the amount of UA level in the blood of a gout patient using the developed HADC-BIL electrode, which ensures the effectiveness of the developed sensor for the sensitive and selective detection of UA from real samples.

KW - UA sensor

KW - carbons

KW - intrinsic doping

KW - ionic liquid

KW - polyphosphazene

UR - https://www.scopus.com/pages/publications/85095986883

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DO - 10.1021/acsanm.0c02466

M3 - Article

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IS - 11

ER -

Heteroatom-Doped Carbon Nanoparticle-Ionic Liquid Composites as Electrochemical Sensors for Uric Acid

Abstract

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Keywords

ASJC Scopus subject areas

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