Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications

Robin Augustine; Alap Ali Zahid; Mian Wang; Thomas J. Webster; Anwarul Hasan

doi:10.1109/EMBC.2019.8857111

Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications

Robin Augustine, Alap Ali Zahid, Mian Wang, Thomas J. Webster, Anwarul Hasan^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Tissue engineering is the use of a combination of cells, biomaterials and appropriate signals to repair or improve the functions of damaged tissues. Our group is exploiting various approaches to effectively encapsulate multiple growth factors in polymeric scaffolds for tissue engineering and wound healing applications. In this report, some of the exciting results from our most recent and ongoing projects are outlined with a focus on the use of connective tissue growth factor (CTGF). CTGF is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis and tissue repair. CTGF can play a major role in tissue regeneration by enhancing cell proliferation and promoting cell migration. CTGF was incorporated to electrospun polymeric fibers to provide sustained release. Experimental results demonstrated the ability of scaffolds incorporated with CTGF to promote cell proliferation and cell migration. This study shows the application potential of the developed scaffolds in various tissue engineering applications.

Original language	English
Title of host publication	2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1066-1069
Number of pages	4
ISBN (Electronic)	9781538613115
DOIs	https://doi.org/10.1109/EMBC.2019.8857111
State	Published - Jul 2019
Externally published	Yes

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/EMBC.2019.8857111

Cite this

Augustine, R., Zahid, A. A., Wang, M., Webster, T. J., & Hasan, A. (2019). Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 1066-1069). Article 8857111 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8857111

Augustine, Robin ; Zahid, Alap Ali ; Wang, Mian et al. / Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1066-1069 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications",

abstract = "Tissue engineering is the use of a combination of cells, biomaterials and appropriate signals to repair or improve the functions of damaged tissues. Our group is exploiting various approaches to effectively encapsulate multiple growth factors in polymeric scaffolds for tissue engineering and wound healing applications. In this report, some of the exciting results from our most recent and ongoing projects are outlined with a focus on the use of connective tissue growth factor (CTGF). CTGF is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis and tissue repair. CTGF can play a major role in tissue regeneration by enhancing cell proliferation and promoting cell migration. CTGF was incorporated to electrospun polymeric fibers to provide sustained release. Experimental results demonstrated the ability of scaffolds incorporated with CTGF to promote cell proliferation and cell migration. This study shows the application potential of the developed scaffolds in various tissue engineering applications.",

author = "Robin Augustine and Zahid, \{Alap Ali\} and Mian Wang and Webster, \{Thomas J.\} and Anwarul Hasan",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.",

year = "2019",

month = jul,

doi = "10.1109/EMBC.2019.8857111",

language = "English",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Augustine, R, Zahid, AA, Wang, M, Webster, TJ & Hasan, A 2019, Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8857111, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 1066-1069. https://doi.org/10.1109/EMBC.2019.8857111

Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications. / Augustine, Robin; Zahid, Alap Ali; Wang, Mian et al.
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1066-1069 8857111 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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AU - Webster, Thomas J.

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AB - Tissue engineering is the use of a combination of cells, biomaterials and appropriate signals to repair or improve the functions of damaged tissues. Our group is exploiting various approaches to effectively encapsulate multiple growth factors in polymeric scaffolds for tissue engineering and wound healing applications. In this report, some of the exciting results from our most recent and ongoing projects are outlined with a focus on the use of connective tissue growth factor (CTGF). CTGF is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis and tissue repair. CTGF can play a major role in tissue regeneration by enhancing cell proliferation and promoting cell migration. CTGF was incorporated to electrospun polymeric fibers to provide sustained release. Experimental results demonstrated the ability of scaffolds incorporated with CTGF to promote cell proliferation and cell migration. This study shows the application potential of the developed scaffolds in various tissue engineering applications.

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Augustine R, Zahid AA, Wang M, Webster TJ, Hasan A. Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1066-1069. 8857111. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2019.8857111

Growth factor releasing core-shell polymeric scaffolds for tissue engineering applications

Abstract

Publication series

Bibliographical note

ASJC Scopus subject areas

Access to Document

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Cite this