Gold-197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs

David T. Hill; Blaine M. Sutton; Anvarhusein A. Isab; Tahir Razi; Peter J. Sadler; Jan M. Trooster; Gijs H.M. Calisu

doi:10.1021/ic00162a034

Gold-197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs

David T. Hill, Blaine M. Sutton, Anvarhusein A. Isab^*, Tahir Razi, Peter J. Sadler, Jan M. Trooster, Gijs H.M. Calisu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Structural information on 11 gold(I) thiolates and 12 phosphine-coordinated gold(I) thiolates has been collected by using ¹⁹⁷Au Mössbauer spectroscopy. The compounds studied include the injectable antiarthritic drugs gold sodium thiomalate (1), gold thioglucose (6), gold sodium thiosulfate (11), and the orally effective (phosphine)gold(I) thiolate auranofin (15). Isomer shifts and quadrupole coupling constants indicate that gold atoms in the 1:1 thiolates are sulfur bonded and two-coordinate. These compounds are polymeric in the solid state. This information complements previous solution studies. The Mossbauer spectra of the (phosphine)gold complexes are characteristic and consistent with a monomeric linear SAuP linkage. The spectral parameters (IS, QS) of the phosphine complexes are approximately 2 mm s^-1 larger than those of the comparable thiolates. The structural and biological significance of these data is discussed.

Original language	English
Pages (from-to)	2936-2942
Number of pages	7
Journal	Inorganic Chemistry
Volume	22
Issue number	20
DOIs	https://doi.org/10.1021/ic00162a034
State	Published - Sep 1983

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

Access to Document

10.1021/ic00162a034

Cite this

@article{dbfdea98371b4bdcaa4c6b237d6244cf,

title = "Gold-197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs",

abstract = "Structural information on 11 gold(I) thiolates and 12 phosphine-coordinated gold(I) thiolates has been collected by using 197Au M{\"o}ssbauer spectroscopy. The compounds studied include the injectable antiarthritic drugs gold sodium thiomalate (1), gold thioglucose (6), gold sodium thiosulfate (11), and the orally effective (phosphine)gold(I) thiolate auranofin (15). Isomer shifts and quadrupole coupling constants indicate that gold atoms in the 1:1 thiolates are sulfur bonded and two-coordinate. These compounds are polymeric in the solid state. This information complements previous solution studies. The Mossbauer spectra of the (phosphine)gold complexes are characteristic and consistent with a monomeric linear SAuP linkage. The spectral parameters (IS, QS) of the phosphine complexes are approximately 2 mm s-1 larger than those of the comparable thiolates. The structural and biological significance of these data is discussed.",

author = "Hill, \{David T.\} and Sutton, \{Blaine M.\} and Isab, \{Anvarhusein A.\} and Tahir Razi and Sadler, \{Peter J.\} and Trooster, \{Jan M.\} and Calisu, \{Gijs H.M.\}",

year = "1983",

month = sep,

doi = "10.1021/ic00162a034",

language = "English",

volume = "22",

pages = "2936--2942",

journal = "Inorganic Chemistry",

issn = "0020-1669",

number = "20",

}

TY - JOUR

T1 - Gold-197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs

AU - Hill, David T.

AU - Sutton, Blaine M.

AU - Isab, Anvarhusein A.

AU - Razi, Tahir

AU - Sadler, Peter J.

AU - Trooster, Jan M.

AU - Calisu, Gijs H.M.

PY - 1983/9

Y1 - 1983/9

N2 - Structural information on 11 gold(I) thiolates and 12 phosphine-coordinated gold(I) thiolates has been collected by using 197Au Mössbauer spectroscopy. The compounds studied include the injectable antiarthritic drugs gold sodium thiomalate (1), gold thioglucose (6), gold sodium thiosulfate (11), and the orally effective (phosphine)gold(I) thiolate auranofin (15). Isomer shifts and quadrupole coupling constants indicate that gold atoms in the 1:1 thiolates are sulfur bonded and two-coordinate. These compounds are polymeric in the solid state. This information complements previous solution studies. The Mossbauer spectra of the (phosphine)gold complexes are characteristic and consistent with a monomeric linear SAuP linkage. The spectral parameters (IS, QS) of the phosphine complexes are approximately 2 mm s-1 larger than those of the comparable thiolates. The structural and biological significance of these data is discussed.

AB - Structural information on 11 gold(I) thiolates and 12 phosphine-coordinated gold(I) thiolates has been collected by using 197Au Mössbauer spectroscopy. The compounds studied include the injectable antiarthritic drugs gold sodium thiomalate (1), gold thioglucose (6), gold sodium thiosulfate (11), and the orally effective (phosphine)gold(I) thiolate auranofin (15). Isomer shifts and quadrupole coupling constants indicate that gold atoms in the 1:1 thiolates are sulfur bonded and two-coordinate. These compounds are polymeric in the solid state. This information complements previous solution studies. The Mossbauer spectra of the (phosphine)gold complexes are characteristic and consistent with a monomeric linear SAuP linkage. The spectral parameters (IS, QS) of the phosphine complexes are approximately 2 mm s-1 larger than those of the comparable thiolates. The structural and biological significance of these data is discussed.

UR - https://www.scopus.com/pages/publications/0039373440

U2 - 10.1021/ic00162a034

DO - 10.1021/ic00162a034

M3 - Article

AN - SCOPUS:0039373440

SN - 0020-1669

VL - 22

SP - 2936

EP - 2942

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 20

ER -

Gold-197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this