Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

Karsten Korschelt; Ruben Ragg; Carmen S. Metzger; Martin Kluenker; Michael Oster; Bastian Barton; Martin Panthöfer; Dennis Strand; Ute Kolb; Mihail Mondeshki; Susanne Strand; Jürgen Brieger; M. Nawaz Tahir; Wolfgang Tremel

doi:10.1039/c6nr09810j

Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

Karsten Korschelt, Ruben Ragg, Carmen S. Metzger, Martin Kluenker, Michael Oster, Bastian Barton, Martin Panthöfer, Dennis Strand, Ute Kolb, Mihail Mondeshki, Susanne Strand, Jürgen Brieger, M. Nawaz Tahir^*, Wolfgang Tremel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide (O₂^-) radicals into molecular oxygen (O₂) and H₂O₂ as a first line of defense against oxidative stress. Here, we show that glycine-functionalized copper(ii) hydroxide nanoparticles (Gly-Cu(OH)₂ NPs) are functional SOD mimics, whereas bulk Cu(OH)₂ is insoluble in water and catalytically inactive. In contrast, Gly-Cu(OH)₂ NPs form water-dispersible mesocrystals with a SOD-like activity that is larger than that of their natural CuZn enzyme counterpart. Based on this finding, we devised an application where Gly-Cu(OH)₂ NPs were incorporated into cigarette filters. Cigarette smoke contains high concentrations of toxic reactive oxygen species (ROS, >10¹⁶ molecules per puff) including superoxide and reactive nitrogen species which lead to the development of chronic and degenerative diseases via oxidative damage and subsequent cell death. Embedded in cigarette filters Gly-Cu(OH)₂ NPs efficiently removed ROS from smoke, thereby protecting lung cancer cell lines from cytotoxic effects. Their stability, ease of production and versatility make them a powerful tool for a wide range of applications in environmental chemistry, biotechnology and medicine.

Original language	English
Pages (from-to)	3952-3960
Number of pages	9
Journal	Nanoscale
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/c6nr09810j
State	Published - 21 Mar 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

General Materials Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity",

abstract = "Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide (O2-) radicals into molecular oxygen (O2) and H2O2 as a first line of defense against oxidative stress. Here, we show that glycine-functionalized copper(ii) hydroxide nanoparticles (Gly-Cu(OH)2 NPs) are functional SOD mimics, whereas bulk Cu(OH)2 is insoluble in water and catalytically inactive. In contrast, Gly-Cu(OH)2 NPs form water-dispersible mesocrystals with a SOD-like activity that is larger than that of their natural CuZn enzyme counterpart. Based on this finding, we devised an application where Gly-Cu(OH)2 NPs were incorporated into cigarette filters. Cigarette smoke contains high concentrations of toxic reactive oxygen species (ROS, >1016 molecules per puff) including superoxide and reactive nitrogen species which lead to the development of chronic and degenerative diseases via oxidative damage and subsequent cell death. Embedded in cigarette filters Gly-Cu(OH)2 NPs efficiently removed ROS from smoke, thereby protecting lung cancer cell lines from cytotoxic effects. Their stability, ease of production and versatility make them a powerful tool for a wide range of applications in environmental chemistry, biotechnology and medicine.",

author = "Karsten Korschelt and Ruben Ragg and Metzger, \{Carmen S.\} and Martin Kluenker and Michael Oster and Bastian Barton and Martin Panth{\"o}fer and Dennis Strand and Ute Kolb and Mihail Mondeshki and Susanne Strand and J{\"u}rgen Brieger and \{Nawaz Tahir\}, M. and Wolfgang Tremel",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

month = mar,

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doi = "10.1039/c6nr09810j",

language = "English",

volume = "9",

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TY - JOUR

T1 - Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

AU - Korschelt, Karsten

AU - Ragg, Ruben

AU - Metzger, Carmen S.

AU - Kluenker, Martin

AU - Oster, Michael

AU - Barton, Bastian

AU - Panthöfer, Martin

AU - Strand, Dennis

AU - Kolb, Ute

AU - Mondeshki, Mihail

AU - Strand, Susanne

AU - Brieger, Jürgen

AU - Nawaz Tahir, M.

AU - Tremel, Wolfgang

PY - 2017/3/21

Y1 - 2017/3/21

N2 - Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide (O2-) radicals into molecular oxygen (O2) and H2O2 as a first line of defense against oxidative stress. Here, we show that glycine-functionalized copper(ii) hydroxide nanoparticles (Gly-Cu(OH)2 NPs) are functional SOD mimics, whereas bulk Cu(OH)2 is insoluble in water and catalytically inactive. In contrast, Gly-Cu(OH)2 NPs form water-dispersible mesocrystals with a SOD-like activity that is larger than that of their natural CuZn enzyme counterpart. Based on this finding, we devised an application where Gly-Cu(OH)2 NPs were incorporated into cigarette filters. Cigarette smoke contains high concentrations of toxic reactive oxygen species (ROS, >1016 molecules per puff) including superoxide and reactive nitrogen species which lead to the development of chronic and degenerative diseases via oxidative damage and subsequent cell death. Embedded in cigarette filters Gly-Cu(OH)2 NPs efficiently removed ROS from smoke, thereby protecting lung cancer cell lines from cytotoxic effects. Their stability, ease of production and versatility make them a powerful tool for a wide range of applications in environmental chemistry, biotechnology and medicine.

AB - Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide (O2-) radicals into molecular oxygen (O2) and H2O2 as a first line of defense against oxidative stress. Here, we show that glycine-functionalized copper(ii) hydroxide nanoparticles (Gly-Cu(OH)2 NPs) are functional SOD mimics, whereas bulk Cu(OH)2 is insoluble in water and catalytically inactive. In contrast, Gly-Cu(OH)2 NPs form water-dispersible mesocrystals with a SOD-like activity that is larger than that of their natural CuZn enzyme counterpart. Based on this finding, we devised an application where Gly-Cu(OH)2 NPs were incorporated into cigarette filters. Cigarette smoke contains high concentrations of toxic reactive oxygen species (ROS, >1016 molecules per puff) including superoxide and reactive nitrogen species which lead to the development of chronic and degenerative diseases via oxidative damage and subsequent cell death. Embedded in cigarette filters Gly-Cu(OH)2 NPs efficiently removed ROS from smoke, thereby protecting lung cancer cell lines from cytotoxic effects. Their stability, ease of production and versatility make them a powerful tool for a wide range of applications in environmental chemistry, biotechnology and medicine.

UR - https://www.scopus.com/pages/publications/85015722972

U2 - 10.1039/c6nr09810j

DO - 10.1039/c6nr09810j

M3 - Article

C2 - 28265620

AN - SCOPUS:85015722972

SN - 2040-3364

VL - 9

SP - 3952

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JO - Nanoscale

JF - Nanoscale

IS - 11

ER -

Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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