Glucosamine-conjugated nanoparticles for the separation of insulin-secreting beta cells

Karthikeyan Narayanan; Alex W.H. Lin; Yuangang Zheng; Nandanan Erathodiyil; Andrew C.A. Wan; Jackie Y. Ying

doi:10.1002/adhm.201200479

Glucosamine-conjugated nanoparticles for the separation of insulin-secreting beta cells

Karthikeyan Narayanan
, Alex W.H. Lin
, Yuangang Zheng
, Nandanan Erathodiyil
, Andrew C.A. Wan^*
, Jackie Y. Ying

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.

Original language	English
Pages (from-to)	1198-1203
Number of pages	6
Journal	Advanced Healthcare Materials
Volume	2
Issue number	9
DOIs	https://doi.org/10.1002/adhm.201200479
State	Published - Sep 2013
Externally published	Yes

Keywords

Beta cell separation
Glucosamine
Iron oxide nanoparticles
Quantum dots

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.201200479

Cite this

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title = "Glucosamine-conjugated nanoparticles for the separation of insulin-secreting beta cells",

abstract = "A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.",

keywords = "Beta cell separation, Glucosamine, Iron oxide nanoparticles, Quantum dots",

author = "Karthikeyan Narayanan and Lin, \{Alex W.H.\} and Yuangang Zheng and Nandanan Erathodiyil and Wan, \{Andrew C.A.\} and Ying, \{Jackie Y.\}",

year = "2013",

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language = "English",

volume = "2",

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AU - Narayanan, Karthikeyan

AU - Lin, Alex W.H.

AU - Zheng, Yuangang

AU - Erathodiyil, Nandanan

AU - Wan, Andrew C.A.

AU - Ying, Jackie Y.

PY - 2013/9

Y1 - 2013/9

N2 - A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.

AB - A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation.

KW - Beta cell separation

KW - Glucosamine

KW - Iron oxide nanoparticles

KW - Quantum dots

UR - https://www.scopus.com/pages/publications/84883699263

U2 - 10.1002/adhm.201200479

DO - 10.1002/adhm.201200479

M3 - Article

C2 - 23471896

AN - SCOPUS:84883699263

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JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 9

ER -

Glucosamine-conjugated nanoparticles for the separation of insulin-secreting beta cells

Abstract

Keywords

ASJC Scopus subject areas

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