Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application

Hany E. Marei; Asmaa Althani; Nahla Afifi; Anwarul Hasan; Thomas Caceci; Ingrid Cifola; Sara Caratelli; Giuseppe Sconocchia; Igea D’Agnano; Carlo Cenciarelli

doi:10.1007/s12672-022-00514-0

Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application

Hany E. Marei^*
, Asmaa Althani
, Nahla Afifi
, Anwarul Hasan
, Thomas Caceci
, Ingrid Cifola
, Sara Caratelli
, Giuseppe Sconocchia
, Igea D’Agnano
, Carlo Cenciarelli

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches.

Original language	English
Article number	49
Journal	Discover Oncology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s12672-022-00514-0
State	Published - Dec 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diagnosis
Extracellular vesicles
GBM
GSCs
Prognosis
Therapy

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Oncology
Endocrinology
Endocrine and Autonomic Systems
Cancer Research

Access to Document

10.1007/s12672-022-00514-0

Cite this

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title = "Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application",

abstract = "EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches.",

keywords = "Diagnosis, Extracellular vesicles, GBM, GSCs, Prognosis, Therapy",

author = "Marei, \{Hany E.\} and Asmaa Althani and Nahla Afifi and Anwarul Hasan and Thomas Caceci and Ingrid Cifola and Sara Caratelli and Giuseppe Sconocchia and Igea D{\textquoteright}Agnano and Carlo Cenciarelli",

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year = "2022",

month = dec,

doi = "10.1007/s12672-022-00514-0",

language = "English",

volume = "13",

journal = "Discover Oncology",

issn = "1868-8497",

publisher = "Springer Science and Business Media B.V.",

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TY - JOUR

T1 - Glioma extracellular vesicles for precision medicine

T2 - prognostic and theragnostic application

AU - Marei, Hany E.

AU - Althani, Asmaa

AU - Afifi, Nahla

AU - Hasan, Anwarul

AU - Caceci, Thomas

AU - Cifola, Ingrid

AU - Caratelli, Sara

AU - Sconocchia, Giuseppe

AU - D’Agnano, Igea

AU - Cenciarelli, Carlo

PY - 2022/12

Y1 - 2022/12

N2 - EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches.

AB - EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Glioblastoma multiforme (GBM) is a kind of grade IV glioma that has a very dismal prognosis despite advancements in diagnostic methods and therapeutic options. The authors discuss advances in understanding the function of extracellular vesicles (EVs), in overall glioma growth, as well as how recent research is uncovering the utility of EVs in glioma diagnostics, prognostic and therapeutics approaches.

KW - Diagnosis

KW - Extracellular vesicles

KW - GBM

KW - GSCs

KW - Prognosis

KW - Therapy

UR - https://www.scopus.com/pages/publications/85132117188

U2 - 10.1007/s12672-022-00514-0

DO - 10.1007/s12672-022-00514-0

M3 - Review article

AN - SCOPUS:85132117188

SN - 1868-8497

VL - 13

JO - Discover Oncology

JF - Discover Oncology

IS - 1

M1 - 49

ER -

Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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