Functionalized magnetic nanoparticles for selective targeting of cells

Wolfgang Tremel; Mohammed Shukoor; Filipe Natalio; Muhammad Tahir; Matthias Wiens; Thomas Schladt; Matthias Barz; Patrick Theato; Heinz Schröder; Werner Müller

doi:10.1557/proc-1241-xx05-03

Functionalized magnetic nanoparticles for selective targeting of cells

Wolfgang Tremel^*, Mohammed Shukoor, Filipe Natalio, Muhammad Tahir, Matthias Wiens, Thomas Schladt, Matthias Barz, Patrick Theato, Heinz Schröder, Werner Müller

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

MnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosinphosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.

Original language	English
Title of host publication	Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging
Publisher	Materials Research Society
Pages	99-104
Number of pages	6
ISBN (Print)	9781605111124
DOIs	https://doi.org/10.1557/proc-1241-xx05-03
State	Published - 2009
Externally published	Yes

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1140
ISSN (Print)	0272-9172

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1557/proc-1241-xx05-03

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Tremel, W., Shukoor, M., Natalio, F., Tahir, M., Wiens, M., Schladt, T., Barz, M., Theato, P., Schröder, H., & Müller, W. (2009). Functionalized magnetic nanoparticles for selective targeting of cells. In Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging (pp. 99-104). (Materials Research Society Symposium Proceedings; Vol. 1140). Materials Research Society. https://doi.org/10.1557/proc-1241-xx05-03

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title = "Functionalized magnetic nanoparticles for selective targeting of cells",

abstract = "MnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosinphosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.",

author = "Wolfgang Tremel and Mohammed Shukoor and Filipe Natalio and Muhammad Tahir and Matthias Wiens and Thomas Schladt and Matthias Barz and Patrick Theato and Heinz Schr{\"o}der and Werner M{\"u}ller",

year = "2009",

doi = "10.1557/proc-1241-xx05-03",

language = "English",

isbn = "9781605111124",

series = "Materials Research Society Symposium Proceedings",

publisher = "Materials Research Society",

pages = "99--104",

booktitle = "Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging",

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Tremel, W, Shukoor, M, Natalio, F, Tahir, M, Wiens, M, Schladt, T, Barz, M, Theato, P, Schröder, H & Müller, W 2009, Functionalized magnetic nanoparticles for selective targeting of cells. in Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging. Materials Research Society Symposium Proceedings, vol. 1140, Materials Research Society, pp. 99-104. https://doi.org/10.1557/proc-1241-xx05-03

Functionalized magnetic nanoparticles for selective targeting of cells. / Tremel, Wolfgang; Shukoor, Mohammed; Natalio, Filipe et al.
Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging. Materials Research Society, 2009. p. 99-104 (Materials Research Society Symposium Proceedings; Vol. 1140).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Functionalized magnetic nanoparticles for selective targeting of cells

AU - Tremel, Wolfgang

AU - Shukoor, Mohammed

AU - Natalio, Filipe

AU - Tahir, Muhammad

AU - Wiens, Matthias

AU - Schladt, Thomas

AU - Barz, Matthias

AU - Theato, Patrick

AU - Schröder, Heinz

AU - Müller, Werner

PY - 2009

Y1 - 2009

N2 - MnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosinphosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.

AB - MnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosinphosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.

UR - https://www.scopus.com/pages/publications/72849127796

U2 - 10.1557/proc-1241-xx05-03

DO - 10.1557/proc-1241-xx05-03

M3 - Conference contribution

AN - SCOPUS:72849127796

SN - 9781605111124

T3 - Materials Research Society Symposium Proceedings

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BT - Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging

PB - Materials Research Society

ER -

Functionalized magnetic nanoparticles for selective targeting of cells

Abstract

Publication series

ASJC Scopus subject areas

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