Functionalized magnetic nanoparticles for selective targeting of cells

Wolfgang Tremel; Mohammed Ibrahim Shukoor; Filipe Natalio; Thomas Schladt; Matthias Ban; Muhammad Nawaz Tahir; Stefan Weber; Rudolf Zentel; Laura Maria Schreiber; Jürgen Brieger; Heinz Christoph Schröder; Werner Müller

Functionalized magnetic nanoparticles for selective targeting of cells

Wolfgang Tremel^*, Mohammed Ibrahim Shukoor, Filipe Natalio, Thomas Schladt, Matthias Ban, Muhammad Nawaz Tahir, Stefan Weber, Rudolf Zentel, Laura Maria Schreiber, Jürgen Brieger, Heinz Christoph Schröder, Werner Müller

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Initiation of pathways that lead to proliferation and chemoresistance by Toll-like receptors (TLRs) is an important factor in cancer progression. Here, we show the response of human cancer cells to TLR signaling inevitably linked to tumor biology. The approach is based on tailored multifunctional magnetic nanoparticles equipped with pathogen-derived ligand (CpG) functioning as TLR agonists to investigate the impact of immune activation on human cancer cells. Magnetic nanoparticles (MnO) were covalently coated with a multifunctional polymer, displaying no cytotoxicity, being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR 9. Both, the particle and the nucleic acid are tagged with fluorescent markers for simultaneous visualization inside the cell. Apart from optical imaging, the magnetism of the particles also allows magnetic resonance imaging of organisms.

Original language	English
Title of host publication	Biological Imaging and Sensing Using Nanoparticle Assemblies
Pages	89-94
Number of pages	6
State	Published - 2010

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1241
ISSN (Print)	0272-9172

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Tremel, W., Shukoor, M. I., Natalio, F., Schladt, T., Ban, M., Tahir, M. N., Weber, S., Zentel, R., Schreiber, L. M., Brieger, J., Schröder, H. C., & Müller, W. (2010). Functionalized magnetic nanoparticles for selective targeting of cells. In Biological Imaging and Sensing Using Nanoparticle Assemblies (pp. 89-94). (Materials Research Society Symposium Proceedings; Vol. 1241).

@inproceedings{b2b2286c5b324613beac66c3524c412e,

title = "Functionalized magnetic nanoparticles for selective targeting of cells",

abstract = "Initiation of pathways that lead to proliferation and chemoresistance by Toll-like receptors (TLRs) is an important factor in cancer progression. Here, we show the response of human cancer cells to TLR signaling inevitably linked to tumor biology. The approach is based on tailored multifunctional magnetic nanoparticles equipped with pathogen-derived ligand (CpG) functioning as TLR agonists to investigate the impact of immune activation on human cancer cells. Magnetic nanoparticles (MnO) were covalently coated with a multifunctional polymer, displaying no cytotoxicity, being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR 9. Both, the particle and the nucleic acid are tagged with fluorescent markers for simultaneous visualization inside the cell. Apart from optical imaging, the magnetism of the particles also allows magnetic resonance imaging of organisms.",

author = "Wolfgang Tremel and Shukoor, {Mohammed Ibrahim} and Filipe Natalio and Thomas Schladt and Matthias Ban and Tahir, {Muhammad Nawaz} and Stefan Weber and Rudolf Zentel and Schreiber, {Laura Maria} and J{\"u}rgen Brieger and Schr{\"o}der, {Heinz Christoph} and Werner M{\"u}ller",

year = "2010",

language = "English",

isbn = "9781617387678",

series = "Materials Research Society Symposium Proceedings",

pages = "89--94",

booktitle = "Biological Imaging and Sensing Using Nanoparticle Assemblies",

}

Functionalized magnetic nanoparticles for selective targeting of cells. / Tremel, Wolfgang; Shukoor, Mohammed Ibrahim; Natalio, Filipe et al.
Biological Imaging and Sensing Using Nanoparticle Assemblies. 2010. p. 89-94 (Materials Research Society Symposium Proceedings; Vol. 1241).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Functionalized magnetic nanoparticles for selective targeting of cells

AU - Tremel, Wolfgang

AU - Shukoor, Mohammed Ibrahim

AU - Natalio, Filipe

AU - Schladt, Thomas

AU - Ban, Matthias

AU - Tahir, Muhammad Nawaz

AU - Weber, Stefan

AU - Zentel, Rudolf

AU - Schreiber, Laura Maria

AU - Brieger, Jürgen

AU - Schröder, Heinz Christoph

AU - Müller, Werner

PY - 2010

Y1 - 2010

N2 - Initiation of pathways that lead to proliferation and chemoresistance by Toll-like receptors (TLRs) is an important factor in cancer progression. Here, we show the response of human cancer cells to TLR signaling inevitably linked to tumor biology. The approach is based on tailored multifunctional magnetic nanoparticles equipped with pathogen-derived ligand (CpG) functioning as TLR agonists to investigate the impact of immune activation on human cancer cells. Magnetic nanoparticles (MnO) were covalently coated with a multifunctional polymer, displaying no cytotoxicity, being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR 9. Both, the particle and the nucleic acid are tagged with fluorescent markers for simultaneous visualization inside the cell. Apart from optical imaging, the magnetism of the particles also allows magnetic resonance imaging of organisms.

AB - Initiation of pathways that lead to proliferation and chemoresistance by Toll-like receptors (TLRs) is an important factor in cancer progression. Here, we show the response of human cancer cells to TLR signaling inevitably linked to tumor biology. The approach is based on tailored multifunctional magnetic nanoparticles equipped with pathogen-derived ligand (CpG) functioning as TLR agonists to investigate the impact of immune activation on human cancer cells. Magnetic nanoparticles (MnO) were covalently coated with a multifunctional polymer, displaying no cytotoxicity, being able to enter cells while carrying foreign DNA (unmethylated CpG) to recognize intracellular TLR 9. Both, the particle and the nucleic acid are tagged with fluorescent markers for simultaneous visualization inside the cell. Apart from optical imaging, the magnetism of the particles also allows magnetic resonance imaging of organisms.

UR - http://www.scopus.com/inward/record.url?scp=77957808361&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:77957808361

SN - 9781617387678

T3 - Materials Research Society Symposium Proceedings

SP - 89

EP - 94

BT - Biological Imaging and Sensing Using Nanoparticle Assemblies

ER -

Functionalized magnetic nanoparticles for selective targeting of cells

Abstract

Publication series

ASJC Scopus subject areas

UN SDGs

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