Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia

Muhammad Mansha; Michela Carlet; Christian Ploner; Georg Gruber; Muhammad Wasim; Gerrit Jan Wiegers; Johannes Rainer; Stephan Geley; Reinhard Kofler

doi:10.1016/j.leukres.2009.06.029

Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia

Muhammad Mansha
, Michela Carlet
, Christian Ploner
, Georg Gruber
, Muhammad Wasim
, Gerrit Jan Wiegers
, Johannes Rainer
, Stephan Geley
, Reinhard Kofler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and are used in the therapy of lymphoid malignancies. SLA (Src-like-adaptor), an inhibitor of T- and B-cell receptor signaling, is a promising candidate derived from expression profiling analyses in children with acute lymphoblastic leukemia (ALL). Over-expression and knock-down experiments in ALL in vitro model revealed that transgenic SLA alone had no effect on survival or cell cycle progression, nor did it affect sensitivity to, or kinetics of, GC-induced apoptosis. Although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC.

Original language	English
Pages (from-to)	529-534
Number of pages	6
Journal	Leukemia Research
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.leukres.2009.06.029
State	Published - Apr 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CCRF-CEM
Functional gene analysis
Glucocorticoid-induced apoptosis
Lentiviral construct
NALM6
PreB697
Signal transduction
Stable transfected cell line

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/j.leukres.2009.06.029

Cite this

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title = "Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia",

abstract = "Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and are used in the therapy of lymphoid malignancies. SLA (Src-like-adaptor), an inhibitor of T- and B-cell receptor signaling, is a promising candidate derived from expression profiling analyses in children with acute lymphoblastic leukemia (ALL). Over-expression and knock-down experiments in ALL in vitro model revealed that transgenic SLA alone had no effect on survival or cell cycle progression, nor did it affect sensitivity to, or kinetics of, GC-induced apoptosis. Although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC.",

keywords = "CCRF-CEM, Functional gene analysis, Glucocorticoid-induced apoptosis, Lentiviral construct, NALM6, PreB697, Signal transduction, Stable transfected cell line",

author = "Muhammad Mansha and Michela Carlet and Christian Ploner and Georg Gruber and Muhammad Wasim and Wiegers, \{Gerrit Jan\} and Johannes Rainer and Stephan Geley and Reinhard Kofler",

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doi = "10.1016/j.leukres.2009.06.029",

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T1 - Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia

AU - Mansha, Muhammad

AU - Carlet, Michela

AU - Ploner, Christian

AU - Gruber, Georg

AU - Wasim, Muhammad

AU - Wiegers, Gerrit Jan

AU - Rainer, Johannes

AU - Geley, Stephan

AU - Kofler, Reinhard

PY - 2010/4

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AB - Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and are used in the therapy of lymphoid malignancies. SLA (Src-like-adaptor), an inhibitor of T- and B-cell receptor signaling, is a promising candidate derived from expression profiling analyses in children with acute lymphoblastic leukemia (ALL). Over-expression and knock-down experiments in ALL in vitro model revealed that transgenic SLA alone had no effect on survival or cell cycle progression, nor did it affect sensitivity to, or kinetics of, GC-induced apoptosis. Although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC.

KW - CCRF-CEM

KW - Functional gene analysis

KW - Glucocorticoid-induced apoptosis

KW - Lentiviral construct

KW - NALM6

KW - PreB697

KW - Signal transduction

KW - Stable transfected cell line

UR - https://www.scopus.com/pages/publications/76749100129

U2 - 10.1016/j.leukres.2009.06.029

DO - 10.1016/j.leukres.2009.06.029

M3 - Article

C2 - 19631983

AN - SCOPUS:76749100129

SN - 0145-2126

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SP - 529

EP - 534

JO - Leukemia Research

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ER -

Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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