Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments

Mingyang Xie; Adnan Shakoor

doi:10.1109/AIM.2019.8868746

Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments

Mingyang Xie, Adnan Shakoor

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Biological cells positioning and reorientation are the two common manipulation techniques involved in many cell-based biomedical applications. All the reported autonomous frameworks that achieve cell position and orientation regulation are in the sense of Lyapunov asymptotic stability within infinite time. This paper introduces a finite-time (FT) control strategy to achieve automated cell position regulation utilizing robot-aided optical tweezers system. Utilizing the dynamic equation of the optically trapped cells, state feedback together with output feedback FT controller is developed. The performance of the developed approach is demonstrated experimentally with both automation of cell transportation and rotational control on human fibroblast cells. The experimental results indicated that the proposed FT control method for the achievement of cell position and orientation regulation is feasible and exhibits faster convergence rate than conventional controllers with similar structures. This work is the first time to apply FT control to achieve cell position regulation using robot-aided optical tweezers.

Original language	English
Title of host publication	Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1646-1651
Number of pages	6
ISBN (Electronic)	9781728124933
DOIs	https://doi.org/10.1109/AIM.2019.8868746
State	Published - Jul 2019
Externally published	Yes
Event	2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019 - Hong Kong, China Duration: 8 Jul 2019 → 12 Jul 2019

Publication series

Name	IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM
Volume	2019-July

Conference

Conference	2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019
Country/Territory	China
City	Hong Kong
Period	8/07/19 → 12/07/19

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

Keywords

Cell position regulation
Cell transportation
Finite-time control
Optical tweezers

ASJC Scopus subject areas

Electrical and Electronic Engineering
Control and Systems Engineering
Computer Science Applications
Software

Access to Document

10.1109/AIM.2019.8868746

Cite this

Xie, M., & Shakoor, A. (2019). Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments. In Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019 (pp. 1646-1651). Article 8868746 (IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM; Vol. 2019-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/AIM.2019.8868746

Xie, Mingyang ; Shakoor, Adnan. / Finite-time control for biological cells manipulation with robot-tweezers system : Theory and experiments. Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1646-1651 (IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM).

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abstract = "Biological cells positioning and reorientation are the two common manipulation techniques involved in many cell-based biomedical applications. All the reported autonomous frameworks that achieve cell position and orientation regulation are in the sense of Lyapunov asymptotic stability within infinite time. This paper introduces a finite-time (FT) control strategy to achieve automated cell position regulation utilizing robot-aided optical tweezers system. Utilizing the dynamic equation of the optically trapped cells, state feedback together with output feedback FT controller is developed. The performance of the developed approach is demonstrated experimentally with both automation of cell transportation and rotational control on human fibroblast cells. The experimental results indicated that the proposed FT control method for the achievement of cell position and orientation regulation is feasible and exhibits faster convergence rate than conventional controllers with similar structures. This work is the first time to apply FT control to achieve cell position regulation using robot-aided optical tweezers.",

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author = "Mingyang Xie and Adnan Shakoor",

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year = "2019",

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doi = "10.1109/AIM.2019.8868746",

language = "English",

series = "IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM",

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Xie, M & Shakoor, A 2019, Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments. in Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019., 8868746, IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM, vol. 2019-July, Institute of Electrical and Electronics Engineers Inc., pp. 1646-1651, 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019, Hong Kong, China, 8/07/19. https://doi.org/10.1109/AIM.2019.8868746

Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments. / Xie, Mingyang; Shakoor, Adnan.
Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1646-1651 8868746 (IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM; Vol. 2019-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Biological cells positioning and reorientation are the two common manipulation techniques involved in many cell-based biomedical applications. All the reported autonomous frameworks that achieve cell position and orientation regulation are in the sense of Lyapunov asymptotic stability within infinite time. This paper introduces a finite-time (FT) control strategy to achieve automated cell position regulation utilizing robot-aided optical tweezers system. Utilizing the dynamic equation of the optically trapped cells, state feedback together with output feedback FT controller is developed. The performance of the developed approach is demonstrated experimentally with both automation of cell transportation and rotational control on human fibroblast cells. The experimental results indicated that the proposed FT control method for the achievement of cell position and orientation regulation is feasible and exhibits faster convergence rate than conventional controllers with similar structures. This work is the first time to apply FT control to achieve cell position regulation using robot-aided optical tweezers.

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Xie M, Shakoor A. Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments. In Proceedings of the 2019 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1646-1651. 8868746. (IEEE/ASME International Conference on Advanced Intelligent Mechatronics, AIM). doi: 10.1109/AIM.2019.8868746

Finite-time control for biological cells manipulation with robot-tweezers system: Theory and experiments

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this