Abstract
Liver cirrhosis is a life-threatening disorder characterized by severe hepatitis C. Early detection of hepatitis C is crucial since HCV infection has few symptoms, and the patient may remain unaware for many years. The early-stage detection can assist in the treatment and prevent further virus transmission. Abnormally varying albumin concentrations in hepatitis C patients can lead to hypoalbuminemia. Herein, a novel Co-Ni/TiO2 core-shell-based electrochemical sensor is developed for facile and ultra-sensitive human serum albumin (HSA) detection in HCV patients. Co-Ni/TiO2 core shells are fabricated via coprecipitation and hydrothermal methods and used for non-enzymatic detection albumin with high sensitivity, selectivity, and lower detection limits. Cyclic voltammetry, chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS) is performed for albumin detection via Co-Ni/TiO2 modified GCE at different scan rates, pH, and concentrations. The linear range and limit of detection (LOD) obtained for the Co-Ni/TiO2 electrode are 0-30 μM and 0.019 μM, respectively. The utility of Co-Ni/TiO2 electrodes is extended to HSA sensing from HCV-infected patients. Albumin recovery at room temperature ranged from 81.0% to 91.3% in diluted human serum samples. The developed electrochemical analysis method is superior for HSA detection and can be a tool for clinical diagnosis in the future.
Original language | English |
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Article number | 097508 |
Journal | Journal of the Electrochemical Society |
Volume | 170 |
Issue number | 9 |
DOIs | |
State | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Electrochemical Society (“ECS”). Published on behalf of ECS by IOP Publishing Limited.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Renewable Energy, Sustainability and the Environment
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Electrochemistry
- Materials Chemistry