Abstract
Nucleic acids are the very essence of life, containing the genetic potential of all organisms. However, the sheer size of nucleic acids makes them susceptible to a variety of environmental insults. Of these, ultraviolet-induced damage to nucleic acids has received extensive attention due to its role in disease. The primary step in ultraviolet-induced damage is the absorption of light and the subsequent electronic and structural dynamics on the excited-state potential energy surface. In this chapter, we will review the use of Raman and resonance Raman spectroscopy as a means of obtaining excited-state structural dynamics. Specifically, the application of Raman and resonance Raman spectroscopy to determine the excited-state structural dynamics of nucleic acids and their components will be discussed.
| Original language | English |
|---|---|
| Title of host publication | Challenges and Advances in Computational Chemistry and Physics |
| Publisher | Springer |
| Pages | 237-263 |
| Number of pages | 27 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
Publication series
| Name | Challenges and Advances in Computational Chemistry and Physics |
|---|---|
| Volume | 5 |
| ISSN (Print) | 2542-4491 |
| ISSN (Electronic) | 2542-4483 |
Bibliographical note
Publisher Copyright:© 2008, Springer Science+Business Media B.V.
Keywords
- Excited-State Structural Dynamics
- Nucleic Acids
- Resonance Raman Spectroscopy
- Thymine
- Uracil
ASJC Scopus subject areas
- Computer Science Applications
- Chemistry (miscellaneous)
- Physics and Astronomy (miscellaneous)