Evaluating Ternary Metal Oxide (TMO)core-shell nanocomposites for the rapid determination of the anti-neoplastic drug Chlorambucil (Leukeran™)by electrochemical approaches

A functional ternary nanocomposite (MnO₂@NiFe₂O₄)with hierarchically grown flower-like core-shell assembly has been prepared through a simple two-step hydrothermal methodology. The crystallographic information of the sample was obtained via X-ray diffraction. The morphological details of spherical NiFe₂O₄ (core)and flower-like MnO₂ (shell)were examined over FE-SEM and TEM; finally, the XPS confirms the successful formation of MnO₂@NiFe₂O₄ ternary nanocomposite. The surface area of finely grown hierarchical MnO₂ flowers on NiFe₂O₄ nanoparticles was measured through BET isothermal studies. The ternary nanocomposite was employed for the specific and sensitive detection of anticancer drug Chlorambucil. Under the well-optimized condition, the graphically plotted calibration curve was attained at MnO₂@NiFe₂O₄/GCE towards the detection of anticancer drug Chlorambucil, which possesses the wider linear range of 0.025–574.5 μM, with the minimal detection limit of 4.68 nM. The feasibility of the sensitive layer has also been inspected on the pharmaceutical sample (oral tablets)and the biological matrix (human urine), whereas the appreciable spike recoveries were obtained.