Evaluating an effective electrocatalyst for the rapid determination of triptan drug (Maxalt™) from (mono and binary) transition metal (Co, Mn, CoMn, MnCo) oxides: Via electrochemical approaches

In this article, an ultra sensitive and selective electrochemical sensor for the detection of Rizatriptan benzoate (RZB) was reported. The rationally designed transition metal oxides (specifically: Co and Mn) have been synthesized using a facile one-step hydrothermal method. The structural and electroanalytical properties of the prepared transition metal oxide (TMO) microstructures were examined using transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), and differential pluse voltammetry (DPV). The prepared microstructures such as Co₃O₄ polyhedrons (PHs), Mn₃O₄ microcubes (MCs), MnCo₂O₄ micro flowers (MFs) and CoMn₂O₄ hollow microspheres (HMs) were employed for the quantification of triptan drug Rizatriptan benzoate (RZB). As the results show, the CoMn₂O₄ HM modified glassy carbon electrode shows an excellent oxidation curve for the detection of RZB, which also retains a wider linear range of 0.015-2.35 μM, and 11.62-732.12 μM, with the minimum detection limit of 8.19 nM. The viability of the sensor fabrication has also been reviewed on a pharmaceutical sample (Maxalt™ oral tablets) and a biotic substance (blood serum), and considerable spike recoveries were also obtained.