Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Nunung Kurniasih; Asep Supriadin; Desi Harneti; Rizky Abdulah; Mohamad Nurul Azmi Bin Mohamad Taib; Unang Supratman

doi:10.15408/jkv.v7i1.20068

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Nunung Kurniasih^*, Asep Supriadin, Desi Harneti, Rizky Abdulah, Mohamad Nurul Azmi Bin Mohamad Taib, Unang Supratman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC₅₀ values of 0.80 and 26.42 µM, respectively.

Original language	English
Pages (from-to)	46-51
Number of pages	6
Journal	Jurnal Kimia Valensi
Volume	7
Issue number	1
DOIs	https://doi.org/10.15408/jkv.v7i1.20068
State	Published - May 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021, Published by Jurnal Kimia Valensi.

Keywords

Aglaia simplicifolia
Ergosterol peroxide
HeLa cervical cancer
IC
stigmasterol

ASJC Scopus subject areas

Chemistry (miscellaneous)
Analytical Chemistry
Inorganic Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.15408/jkv.v7i1.20068

Cite this

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title = "Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines",

abstract = "Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.",

keywords = "Aglaia simplicifolia, Ergosterol peroxide, HeLa cervical cancer, IC, stigmasterol",

author = "Nunung Kurniasih and Asep Supriadin and Desi Harneti and Rizky Abdulah and Taib, \{Mohamad Nurul Azmi Bin Mohamad\} and Unang Supratman",

note = "Publisher Copyright: {\textcopyright} 2021, Published by Jurnal Kimia Valensi.",

year = "2021",

month = may,

doi = "10.15408/jkv.v7i1.20068",

language = "English",

volume = "7",

pages = "46--51",

journal = "Jurnal Kimia Valensi",

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publisher = "State Islamic University Syarif Hidayatullah Jakarta, Faculty of Science and Technology, Department of Chemistry",

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T1 - Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

AU - Kurniasih, Nunung

AU - Supriadin, Asep

AU - Harneti, Desi

AU - Abdulah, Rizky

AU - Taib, Mohamad Nurul Azmi Bin Mohamad

AU - Supratman, Unang

PY - 2021/5

Y1 - 2021/5

N2 - Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

AB - Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

KW - Aglaia simplicifolia

KW - Ergosterol peroxide

KW - HeLa cervical cancer

KW - IC

KW - stigmasterol

UR - https://www.scopus.com/pages/publications/85123785168

U2 - 10.15408/jkv.v7i1.20068

DO - 10.15408/jkv.v7i1.20068

M3 - Article

AN - SCOPUS:85123785168

SN - 2460-6065

VL - 7

SP - 46

EP - 51

JO - Jurnal Kimia Valensi

JF - Jurnal Kimia Valensi

IS - 1

ER -

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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