Abstract
Racemization is the key step to turn a kinetic resolution (KR), which suffers from the well-known drawback of being limited to a maximum yield of 50% with high enantiopurity, into a dynamic kinetic resolution (DKR) process. Enzyme-based racemization of enantiopure alcohols and amines has gained significant interest in recent years. This review covers recent advances in enzyme-based racemization approaches and their potential applications in bi-enzymatic DKR.
| Original language | English |
|---|---|
| Pages (from-to) | 147-157 |
| Number of pages | 11 |
| Journal | Chirality |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Feb 2020 |
Bibliographical note
Publisher Copyright:© 2019 Wiley Periodicals, Inc.
Keywords
- biocatalysis
- dynamic kinetic resolution
- enantiopure alcohols
- enantiopure amines
- racemization
ASJC Scopus subject areas
- Analytical Chemistry
- Catalysis
- Pharmacology
- Drug Discovery
- Spectroscopy
- Organic Chemistry
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