Enzymatic production of both enantiomers of rhododendrol

Musa M. Musa

doi:10.14233/ajchem.2014.16581

Enzymatic production of both enantiomers of rhododendrol

Musa M. Musa^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

An asymmetric synthetic approach to produce (R)- and (S)-rhododendrol is described. W110A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (W110A Te SADH), an (S)-specific mutant of TeSADH, is used in this approach. The enantioselective reduction of 4-(4'-hydroxyphenyl)-2-butanone catalyzed by W110A TeSADH yielded (S)-rhododendrol, the Prelog product. The anti-Prelog product, (R)-rhododendrol, is produced from (rac)-rhododendrol through enantiospecific kinetic resolution catalyzed by W110A TeSADH.

Original language	English
Pages (from-to)	6719-6721
Number of pages	3
Journal	Asian Journal of Chemistry
Volume	26
Issue number	20
DOIs	https://doi.org/10.14233/ajchem.2014.16581
State	Published - 2014

Keywords

Alcohol dehydrogenases
Asymmetric reduction
Biotransformations
Kinetic resolution
Redox reactions
Rhododendrol

ASJC Scopus subject areas

General Chemistry

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10.14233/ajchem.2014.16581

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title = "Enzymatic production of both enantiomers of rhododendrol",

abstract = "An asymmetric synthetic approach to produce (R)- and (S)-rhododendrol is described. W110A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (W110A Te SADH), an (S)-specific mutant of TeSADH, is used in this approach. The enantioselective reduction of 4-(4'-hydroxyphenyl)-2-butanone catalyzed by W110A TeSADH yielded (S)-rhododendrol, the Prelog product. The anti-Prelog product, (R)-rhododendrol, is produced from (rac)-rhododendrol through enantiospecific kinetic resolution catalyzed by W110A TeSADH.",

keywords = "Alcohol dehydrogenases, Asymmetric reduction, Biotransformations, Kinetic resolution, Redox reactions, Rhododendrol",

author = "Musa, {Musa M.}",

year = "2014",

doi = "10.14233/ajchem.2014.16581",

language = "English",

volume = "26",

pages = "6719--6721",

journal = "Asian Journal of Chemistry",

issn = "0970-7077",

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T1 - Enzymatic production of both enantiomers of rhododendrol

AU - Musa, Musa M.

PY - 2014

Y1 - 2014

N2 - An asymmetric synthetic approach to produce (R)- and (S)-rhododendrol is described. W110A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (W110A Te SADH), an (S)-specific mutant of TeSADH, is used in this approach. The enantioselective reduction of 4-(4'-hydroxyphenyl)-2-butanone catalyzed by W110A TeSADH yielded (S)-rhododendrol, the Prelog product. The anti-Prelog product, (R)-rhododendrol, is produced from (rac)-rhododendrol through enantiospecific kinetic resolution catalyzed by W110A TeSADH.

AB - An asymmetric synthetic approach to produce (R)- and (S)-rhododendrol is described. W110A Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase (W110A Te SADH), an (S)-specific mutant of TeSADH, is used in this approach. The enantioselective reduction of 4-(4'-hydroxyphenyl)-2-butanone catalyzed by W110A TeSADH yielded (S)-rhododendrol, the Prelog product. The anti-Prelog product, (R)-rhododendrol, is produced from (rac)-rhododendrol through enantiospecific kinetic resolution catalyzed by W110A TeSADH.

KW - Alcohol dehydrogenases

KW - Asymmetric reduction

KW - Biotransformations

KW - Kinetic resolution

KW - Redox reactions

KW - Rhododendrol

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U2 - 10.14233/ajchem.2014.16581

DO - 10.14233/ajchem.2014.16581

M3 - Article

AN - SCOPUS:84907835538

SN - 0970-7077

VL - 26

SP - 6719

EP - 6721

JO - Asian Journal of Chemistry

JF - Asian Journal of Chemistry

IS - 20

ER -

Enzymatic production of both enantiomers of rhododendrol

Abstract

Keywords

ASJC Scopus subject areas

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