Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing

Alap Ali Zahid; Rashid Ahmed; Syed Raza Ur Rehman; Robin Augustine; Anwarul Hasan

Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing

Alap Ali Zahid, Rashid Ahmed, Syed Raza Ur Rehman, Robin Augustine, Anwarul Hasan^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Statement of Purpose: Nitric oxide (NO) released from endothelial cells endogenously promotes angiogenesis. The potential of using exogenous NO for enhancing faster healing of acute and chronic wounds have also been supported by earlier work (Wo, Y., Biomater. Sci, 2016. 4(8), 1161-1183). However, fast and burst release of NO from its donors such as S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has limited its applicability in faster healing of wounds. Herein, we report the development of an NO releasing chitosan-PVA hydrogel incorporated with NO donor (SNAP). The result showed that the release profile of NO releasing chitosan-PVA hydrogel maintains a controlled and sustained release of NO for five days. The in vivo studies showed a significant increase in the size, number and branching network of newly formed blood vessels in chick embryo model. The study described here exhibits that NO releasing chitosan-PVA hydrogels could be an effective dressing for faster healing of acute and chronic wounds.

Original language	English
Title of host publication	Society for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publication	The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
Publisher	Society for Biomaterials
Pages	595
Number of pages	1
ISBN (Electronic)	9781510883901
State	Published - 2019
Externally published	Yes
Event	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 3 Apr 2019 → 6 Apr 2019

Publication series

Name	Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume	40
ISSN (Print)	1526-7547

Conference

Conference	42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/Territory	United States
City	Seattle
Period	3/04/19 → 6/04/19

Bibliographical note

Publisher Copyright:
© 2019 Omnipress - All rights reserved.

ASJC Scopus subject areas

Biochemistry
Biophysics
Biotechnology
Biomaterials
Materials Chemistry

Cite this

Zahid, A. A., Ahmed, R., Rehman, S. R. U., Augustine, R., & Hasan, A. (2019). Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 595). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Zahid, Alap Ali ; Ahmed, Rashid ; Rehman, Syed Raza Ur et al. / Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. pp. 595 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

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title = "Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing",

abstract = "Statement of Purpose: Nitric oxide (NO) released from endothelial cells endogenously promotes angiogenesis. The potential of using exogenous NO for enhancing faster healing of acute and chronic wounds have also been supported by earlier work (Wo, Y., Biomater. Sci, 2016. 4(8), 1161-1183). However, fast and burst release of NO from its donors such as S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has limited its applicability in faster healing of wounds. Herein, we report the development of an NO releasing chitosan-PVA hydrogel incorporated with NO donor (SNAP). The result showed that the release profile of NO releasing chitosan-PVA hydrogel maintains a controlled and sustained release of NO for five days. The in vivo studies showed a significant increase in the size, number and branching network of newly formed blood vessels in chick embryo model. The study described here exhibits that NO releasing chitosan-PVA hydrogels could be an effective dressing for faster healing of acute and chronic wounds.",

author = "Zahid, \{Alap Ali\} and Rashid Ahmed and Rehman, \{Syed Raza Ur\} and Robin Augustine and Anwarul Hasan",

note = "Publisher Copyright: {\textcopyright} 2019 Omnipress - All rights reserved.; 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence ; Conference date: 03-04-2019 Through 06-04-2019",

year = "2019",

language = "English",

series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",

publisher = "Society for Biomaterials",

pages = "595",

booktitle = "Society for Biomaterials Annual Meeting and Exposition 2019",

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Zahid, AA, Ahmed, R, Rehman, SRU, Augustine, R & Hasan, A 2019, Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, pp. 595, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 3/04/19.

Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing. / Zahid, Alap Ali; Ahmed, Rashid; Rehman, Syed Raza Ur et al.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. p. 595 (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing

AU - Zahid, Alap Ali

AU - Ahmed, Rashid

AU - Rehman, Syed Raza Ur

AU - Augustine, Robin

AU - Hasan, Anwarul

PY - 2019

Y1 - 2019

N2 - Statement of Purpose: Nitric oxide (NO) released from endothelial cells endogenously promotes angiogenesis. The potential of using exogenous NO for enhancing faster healing of acute and chronic wounds have also been supported by earlier work (Wo, Y., Biomater. Sci, 2016. 4(8), 1161-1183). However, fast and burst release of NO from its donors such as S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has limited its applicability in faster healing of wounds. Herein, we report the development of an NO releasing chitosan-PVA hydrogel incorporated with NO donor (SNAP). The result showed that the release profile of NO releasing chitosan-PVA hydrogel maintains a controlled and sustained release of NO for five days. The in vivo studies showed a significant increase in the size, number and branching network of newly formed blood vessels in chick embryo model. The study described here exhibits that NO releasing chitosan-PVA hydrogels could be an effective dressing for faster healing of acute and chronic wounds.

AB - Statement of Purpose: Nitric oxide (NO) released from endothelial cells endogenously promotes angiogenesis. The potential of using exogenous NO for enhancing faster healing of acute and chronic wounds have also been supported by earlier work (Wo, Y., Biomater. Sci, 2016. 4(8), 1161-1183). However, fast and burst release of NO from its donors such as S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has limited its applicability in faster healing of wounds. Herein, we report the development of an NO releasing chitosan-PVA hydrogel incorporated with NO donor (SNAP). The result showed that the release profile of NO releasing chitosan-PVA hydrogel maintains a controlled and sustained release of NO for five days. The in vivo studies showed a significant increase in the size, number and branching network of newly formed blood vessels in chick embryo model. The study described here exhibits that NO releasing chitosan-PVA hydrogels could be an effective dressing for faster healing of acute and chronic wounds.

UR - https://www.scopus.com/pages/publications/85065428300

M3 - Conference contribution

AN - SCOPUS:85065428300

T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

SP - 595

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

Y2 - 3 April 2019 through 6 April 2019

ER -

Zahid AA, Ahmed R, Rehman SRU, Augustine R, Hasan A. Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. p. 595. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).

Enhanced angiogenesis with nitric oxide releasing chitosan-pva hydrogel for wound healing

Abstract

Publication series

Conference

Bibliographical note

ASJC Scopus subject areas

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Cite this