Enantioselective [4 + 2]-Annulation of Oxadienes and Allenones Catalyzed by an Amino Acid Derived Phosphine: Synthesis of Functionalized Dihydropyrans

Huanzhen Ni; Weijun Yao; Abdul Waheed; Nisar Ullah; Yixin Lu

doi:10.1021/acs.orglett.6b00760

Enantioselective [4 + 2]-Annulation of Oxadienes and Allenones Catalyzed by an Amino Acid Derived Phosphine: Synthesis of Functionalized Dihydropyrans

Huanzhen Ni, Weijun Yao, Abdul Waheed, Nisar Ullah^*, Yixin Lu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

An enantioselective [4 + 2]-annulation process between cyano-activated oxadienes and allenones is developed. An l-valine-derived phosphine was efficient in catalyzing the reaction, and a wide range of highly functionalized dihydropyrans were prepared in high yields and with excellent enantioselectivities.

Original language	English
Pages (from-to)	2138-2141
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	9
DOIs	https://doi.org/10.1021/acs.orglett.6b00760
State	Published - 6 May 2016

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Publisher Copyright:
© 2016 American Chemical Society.

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "An enantioselective [4 + 2]-annulation process between cyano-activated oxadienes and allenones is developed. An l-valine-derived phosphine was efficient in catalyzing the reaction, and a wide range of highly functionalized dihydropyrans were prepared in high yields and with excellent enantioselectivities.",

author = "Huanzhen Ni and Weijun Yao and Abdul Waheed and Nisar Ullah and Yixin Lu",

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T2 - Synthesis of Functionalized Dihydropyrans

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AU - Yao, Weijun

AU - Waheed, Abdul

AU - Ullah, Nisar

AU - Lu, Yixin

PY - 2016/5/6

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AB - An enantioselective [4 + 2]-annulation process between cyano-activated oxadienes and allenones is developed. An l-valine-derived phosphine was efficient in catalyzing the reaction, and a wide range of highly functionalized dihydropyrans were prepared in high yields and with excellent enantioselectivities.

UR - https://www.scopus.com/pages/publications/84969672787

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Enantioselective [4 + 2]-Annulation of Oxadienes and Allenones Catalyzed by an Amino Acid Derived Phosphine: Synthesis of Functionalized Dihydropyrans

Abstract

Bibliographical note

ASJC Scopus subject areas

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