ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

Emi Norzehan Mohamad Mahbob; Mohamad Syahrizal Ahmad; Illyas Md Isa; Norhayati Hashim; Anwar Ul-Hamid; Mohamad Idris Saidin; Suyanta M. Si

doi:10.4314/bcse.v37i4.4

ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

Emi Norzehan Mohamad Mahbob
, Mohamad Syahrizal Ahmad^*
, Illyas Md Isa^*
, Norhayati Hashim
, Anwar Ul-Hamid
, Mohamad Idris Saidin
, Suyanta M. Si

^*Corresponding author for this work

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Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10^-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10^-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.

Original language	English
Pages (from-to)	845-857
Number of pages	13
Journal	Bulletin of the Chemical Society of Ethiopia
Volume	37
Issue number	4
DOIs	https://doi.org/10.4314/bcse.v37i4.4
State	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 Chemical Society of Ethiopia and The Authors.

Keywords

Dopamine
Electrochemical sensor
MWCNT
Pyrazolone
Voltammetry

ASJC Scopus subject areas

General Chemistry

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10.4314/bcse.v37i4.4

Cite this

@article{c9b6158324584f40bddd95602f54634b,

title = "ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE",

abstract = "This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.",

keywords = "Dopamine, Electrochemical sensor, MWCNT, Pyrazolone, Voltammetry",

author = "Mahbob, \{Emi Norzehan Mohamad\} and Ahmad, \{Mohamad Syahrizal\} and Isa, \{Illyas Md\} and Norhayati Hashim and Anwar Ul-Hamid and Saidin, \{Mohamad Idris\} and Si, \{Suyanta M.\}",

note = "Publisher Copyright: {\textcopyright} 2023 Chemical Society of Ethiopia and The Authors.",

year = "2023",

doi = "10.4314/bcse.v37i4.4",

language = "English",

volume = "37",

pages = "845--857",

journal = "Bulletin of the Chemical Society of Ethiopia",

issn = "1011-3924",

publisher = "Chemical Society of Ethiopia",

number = "4",

}

ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE. / Mahbob, Emi Norzehan Mohamad; Ahmad, Mohamad Syahrizal; Isa, Illyas Md et al.
In: Bulletin of the Chemical Society of Ethiopia, Vol. 37, No. 4, 2023, p. 845-857.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

AU - Mahbob, Emi Norzehan Mohamad

AU - Ahmad, Mohamad Syahrizal

AU - Isa, Illyas Md

AU - Hashim, Norhayati

AU - Ul-Hamid, Anwar

AU - Saidin, Mohamad Idris

AU - Si, Suyanta M.

PY - 2023

Y1 - 2023

N2 - This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.

AB - This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.

KW - Dopamine

KW - Electrochemical sensor

KW - MWCNT

KW - Pyrazolone

KW - Voltammetry

UR - https://www.scopus.com/pages/publications/85162014337

U2 - 10.4314/bcse.v37i4.4

DO - 10.4314/bcse.v37i4.4

M3 - Article

AN - SCOPUS:85162014337

SN - 1011-3924

VL - 37

SP - 845

EP - 857

JO - Bulletin of the Chemical Society of Ethiopia

JF - Bulletin of the Chemical Society of Ethiopia

IS - 4

ER -

ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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