ELECTROCHEMICAL SENSOR OF MULTIWALLED CARBON NANOTUBE ELECTRODE MODIFIED BY 1-PHENYL-3-METHYL-4-ORTHOFLUORO BENZOYL-5-PYRAZOLONE FOR SENSING DOPAMINE

Emi Norzehan Mohamad Mahbob, Mohamad Syahrizal Ahmad*, Illyas Md Isa*, Norhayati Hashim, Anwar Ul-Hamid, Mohamad Idris Saidin, Suyanta M. Si

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection.

Original languageEnglish
Pages (from-to)845-857
Number of pages13
JournalBulletin of the Chemical Society of Ethiopia
Volume37
Issue number4
DOIs
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 Chemical Society of Ethiopia and The Authors.

Keywords

  • Dopamine
  • Electrochemical sensor
  • MWCNT
  • Pyrazolone
  • Voltammetry

ASJC Scopus subject areas

  • General Chemistry

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