TY - JOUR
T1 - Electrochemical Investigation of Gold Nanoparticle-Modified Glassy Carbon Electrode and its Application in Ketoconazole Determination
AU - Alshalalfeh, Mutasem M.
AU - Sohail, Manzar
AU - Saleh, Tawfik A.
AU - Aziz, Md Abdul
N1 - Publisher Copyright:
© 2016 CSIRO.
PY - 2016
Y1 - 2016
N2 - Ketoconazole (KCZ) is an extensively used antifungal compound and is an active ingredient of anti-scaling shampoos, pomades, and skin ointments. In this work, the cyclic voltammetric behaviour of KCZ was studied with a gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode. The conditions for KCZ determination with GC/AuNP were optimised to achieve the best possible response. A pre-adsorption voltage of-1.6V, a deposition time of 120s, pH 4.0, and stirring of the KCZ solution during deposition were chosen as the optimum conditions for KCZ determination. The anodic peak at 0.697V was used for KCZ determination. A linear concentration range of 20-100M (R2≤0.9986) and a detection limit of 2.3M (3σ) was achieved for KCZ using the GC/AuNP electrode.
AB - Ketoconazole (KCZ) is an extensively used antifungal compound and is an active ingredient of anti-scaling shampoos, pomades, and skin ointments. In this work, the cyclic voltammetric behaviour of KCZ was studied with a gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode. The conditions for KCZ determination with GC/AuNP were optimised to achieve the best possible response. A pre-adsorption voltage of-1.6V, a deposition time of 120s, pH 4.0, and stirring of the KCZ solution during deposition were chosen as the optimum conditions for KCZ determination. The anodic peak at 0.697V was used for KCZ determination. A linear concentration range of 20-100M (R2≤0.9986) and a detection limit of 2.3M (3σ) was achieved for KCZ using the GC/AuNP electrode.
UR - https://www.scopus.com/pages/publications/84995790154
U2 - 10.1071/CH16072
DO - 10.1071/CH16072
M3 - Article
AN - SCOPUS:84995790154
SN - 0004-9425
VL - 69
SP - 1314
EP - 1320
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
IS - 11
ER -