Abstract
The synthesis of dl-elaeokanine-A and dl-elaeokanine-C is described by an approach which utilizes a nitrone cyclo-addition to generate a β-aminoketone, which upon annulation produces one or the other of the title alkaloids depending upon conditions.
Original language | English |
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Pages (from-to) | 4445-4448 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 20 |
Issue number | 46 |
DOIs | |
State | Published - 1979 |
Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgement - We wish to thank the Institute of General Medical Sciences of the NIH for financial assistance (GM 25303). Moreover, we are grateful to Dr. J. A. Lamberton (CSIRO, Melbourne) for the NMR and IR spectra of natural d-elaeokanine-Aa nd dl-elaeokanine-C,a nd for IR (KBr) spectra of the methiodide of both natural and synthetic elaeokanine-C.
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry