TY - GEN
T1 - Effect of self-gating on action potential firing at neuromuscular junction
AU - Rahman, M. Mostafizur
AU - Mahmud, Mufti
AU - Vassanelli, Stefano
PY - 2011
Y1 - 2011
N2 - The neuromuscular junction (NMJ) is the place where the axon terminal of motoneuron connects the endplate of a muscle fiber. During this transduction a large depolarization (endplate potential) caused by the nerve impulse opens a large number of voltage-sensitive sodium channels at the post-junctional terminal. As a result, action potentials are generated and propagated along the muscle fiber causing contraction. This work shows simulated results of the voltage-dependent sodium channels' firing behavior at the NMJ using a mathematical model. It is found that the firing behavior of the sodium channels change basing on their activation and inactivation kinetics which are highly influenced by the self-gating behavior of the sodium conductances. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ and decrease threshold for firing.
AB - The neuromuscular junction (NMJ) is the place where the axon terminal of motoneuron connects the endplate of a muscle fiber. During this transduction a large depolarization (endplate potential) caused by the nerve impulse opens a large number of voltage-sensitive sodium channels at the post-junctional terminal. As a result, action potentials are generated and propagated along the muscle fiber causing contraction. This work shows simulated results of the voltage-dependent sodium channels' firing behavior at the NMJ using a mathematical model. It is found that the firing behavior of the sodium channels change basing on their activation and inactivation kinetics which are highly influenced by the self-gating behavior of the sodium conductances. The simulation results showed that self-gating of sodium channels increase conduction efficiency at the NMJ and decrease threshold for firing.
KW - Self-gating
KW - action potentials
KW - neuromuscular junction
KW - voltage-dependent sodium channels
UR - https://www.scopus.com/pages/publications/84055176176
U2 - 10.1109/IEMBS.2011.6091014
DO - 10.1109/IEMBS.2011.6091014
M3 - Conference contribution
AN - SCOPUS:84055176176
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4082
EP - 4085
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
ER -