Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells

Sarah Almofty*, Vijaya Ravinayagam, Norah Alghamdi, Wejdan Alghamdi, Zainab Albazroun, Layan Almulla, Sultan Akhtar, Ali Awad Almofleh, Gazali Tanimu, H. Dafalla, B. Rabindran Jermy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cerium oxide nanoparticles (CeO2 NPs) and flavonoid curcumin that has been widely studied for treating diseases involving high reactive oxygen species (ROS). In nanotherapeutics, the particle size, shape, metal oxide dispersity and surface properties of nanocarriers are vital for drug delivery and therapeutic efficiency. Here, cisplatin release behavior on cerium impregnated two different shaped nanocarriers, CeO2/monodispersed spherical silica (Sil) and CeO2/halloysite (Hal) nanotube was studied for potential anti-cancer therapies. For comparison, CeO2 impregnated mesoporous silica MCM-41, SBA-16, Hydroxyapatite and clay were prepared. Subsequently, the nanocomposites were coated with curcumin (25% wt/wt), and cisplatin (Cp) functionalization (5% wt/wt). 5wt%CeO2/Hal/Cp and 5wt%CeO2/Sil/Cp samples were pegylated using lyophilization technique. Physico-chemical analyses revealed the nanosized distribution of CeO2 and functionalization of cisplatin and curcumin. Cp release was studied using automated Franz cell and dialysis membrane techniques. The different structured nanocarriers delivering mechanism was studied by determining the drug kinetic release using four different kinetic models (first order, second order, Higuchi and Korsmeyer-Peppas). In vitro cytotoxicity assay of nano formulations along with free cisplatin and curcumin (Cur) were tested against the breast cancer cell line (MCF-7) for multiple timepoints by MTT assay. The results reveled the efficacy of 5wt%CeO2/Sil/Cp/Cur nanoparticles in delivering cisplatin. On the other hand, 5wt%CeO2/Hal/Cur nanoparticles enhanced the uptake of curcumin in comparison to free curcumin. Overall, pegylated CeO2/Silica nano formulation demonstrated an effective carrier to cisplatin for potential treatment of breast cancer.

Original languageEnglish
Article number100169
JournalOpenNano
Volume13
DOIs
StatePublished - Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Keywords

  • Breast cancer
  • Cerium nanoparticles
  • Cisplatin
  • Curcumin
  • Halloysite
  • Silica

ASJC Scopus subject areas

  • Internal Medicine
  • Biotechnology
  • Pharmaceutical Science
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells'. Together they form a unique fingerprint.

Cite this