dsRNA-functionalized multifunctional γ-Fe2O3 nanocrystals: A tool for targeting cell surface receptors

Mohammed Ibrahim Shukoor; Filipe Natalio; Nadine Metz; Natalie Glube; Muhammad Nawaz Tahir; Helen Annal Therese; Vadim Ksenofontov; Patrick Theato; Peter Langguth; Jean Paul Boissel; Heinz C. Schröder; Werner E.G. Müller; Wolfgang Tremel

doi:10.1002/anie.200704735

dsRNA-functionalized multifunctional γ-Fe₂O₃ nanocrystals: A tool for targeting cell surface receptors

Mohammed Ibrahim Shukoor
, Filipe Natalio
, Nadine Metz
, Natalie Glube
, Muhammad Nawaz Tahir
, Helen Annal Therese
, Vadim Ksenofontov
, Patrick Theato
, Peter Langguth
, Jean Paul Boissel
, Heinz C. Schröder
, Werner E.G. Müller
, Wolfgang Tremel

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

(Figure Presented) Specific cell recognition: Magnetic g-Fe ₂O₃ nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic-polycytidylic acid [poly-(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki-1 cells. The expression of TLR3 on the Caki-1 cells was demonstrated independently by RT-PCR and immunostaining techniques.

Original language	English
Pages (from-to)	4748-4752
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	25
DOIs	https://doi.org/10.1002/anie.200704735
State	Published - 9 Jun 2008
Externally published	Yes

Keywords

Biosensors
Cell recognition
Cell surface receptors
Maghemite
Nanoparticles

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.200704735

Cite this

Shukoor, M. I., Natalio, F., Metz, N., Glube, N., Tahir, M. N., Therese, H. A., Ksenofontov, V., Theato, P., Langguth, P., Boissel, J. P., Schröder, H. C., Müller, W. E. G., & Tremel, W. (2008). dsRNA-functionalized multifunctional γ-Fe₂O₃ nanocrystals: A tool for targeting cell surface receptors. Angewandte Chemie - International Edition, 47(25), 4748-4752. https://doi.org/10.1002/anie.200704735

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title = "dsRNA-functionalized multifunctional γ-Fe2O3 nanocrystals: A tool for targeting cell surface receptors",

abstract = "(Figure Presented) Specific cell recognition: Magnetic g-Fe 2O3 nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic-polycytidylic acid [poly-(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki-1 cells. The expression of TLR3 on the Caki-1 cells was demonstrated independently by RT-PCR and immunostaining techniques.",

keywords = "Biosensors, Cell recognition, Cell surface receptors, Maghemite, Nanoparticles",

author = "Shukoor, \{Mohammed Ibrahim\} and Filipe Natalio and Nadine Metz and Natalie Glube and Tahir, \{Muhammad Nawaz\} and Therese, \{Helen Annal\} and Vadim Ksenofontov and Patrick Theato and Peter Langguth and Boissel, \{Jean Paul\} and Schr{\"o}der, \{Heinz C.\} and M{\"u}ller, \{Werner E.G.\} and Wolfgang Tremel",

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month = jun,

day = "9",

doi = "10.1002/anie.200704735",

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Shukoor, MI, Natalio, F, Metz, N, Glube, N, Tahir, MN, Therese, HA, Ksenofontov, V, Theato, P, Langguth, P, Boissel, JP, Schröder, HC, Müller, WEG & Tremel, W 2008, 'dsRNA-functionalized multifunctional γ-Fe₂O₃ nanocrystals: A tool for targeting cell surface receptors', Angewandte Chemie - International Edition, vol. 47, no. 25, pp. 4748-4752. https://doi.org/10.1002/anie.200704735

TY - JOUR

T1 - dsRNA-functionalized multifunctional γ-Fe2O3 nanocrystals

T2 - A tool for targeting cell surface receptors

AU - Shukoor, Mohammed Ibrahim

AU - Natalio, Filipe

AU - Metz, Nadine

AU - Glube, Natalie

AU - Tahir, Muhammad Nawaz

AU - Therese, Helen Annal

AU - Ksenofontov, Vadim

AU - Theato, Patrick

AU - Langguth, Peter

AU - Boissel, Jean Paul

AU - Schröder, Heinz C.

AU - Müller, Werner E.G.

AU - Tremel, Wolfgang

PY - 2008/6/9

Y1 - 2008/6/9

N2 - (Figure Presented) Specific cell recognition: Magnetic g-Fe 2O3 nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic-polycytidylic acid [poly-(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki-1 cells. The expression of TLR3 on the Caki-1 cells was demonstrated independently by RT-PCR and immunostaining techniques.

AB - (Figure Presented) Specific cell recognition: Magnetic g-Fe 2O3 nanoparticles (MNPs) functionalized with a fluorescently labeled polymer and polyinosinic-polycytidylic acid [poly-(I:C)] allow the specific visualizion of the TLR3 receptors on the the surface of Caki-1 cells. The expression of TLR3 on the Caki-1 cells was demonstrated independently by RT-PCR and immunostaining techniques.

KW - Biosensors

KW - Cell recognition

KW - Cell surface receptors

KW - Maghemite

KW - Nanoparticles

UR - https://www.scopus.com/pages/publications/48849109669

U2 - 10.1002/anie.200704735

DO - 10.1002/anie.200704735

M3 - Article

C2 - 18481347

AN - SCOPUS:48849109669

SN - 1433-7851

VL - 47

SP - 4748

EP - 4752

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 25

ER -