Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies

Shahbaz Shamim; Khalid Mohammed Khan; Muhammad Ali; Mohammad Mahdavi; Uzma Salar; Maryam Mohammadi-Khanaposhtani; Mohammad Ali Faramarzi; Nisar Ullah; Muhammad Taha

doi:10.4155/fmc-2023-0057

Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies

Shahbaz Shamim, Khalid Mohammed Khan^*, Muhammad Ali, Mohammad Mahdavi, Uzma Salar, Maryam Mohammadi-Khanaposhtani, Mohammad Ali Faramarzi, Nisar Ullah, Muhammad Taha

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35 ± 0.34 to 564.41 ± 0.91 μM, as the standard acarbose, IC50 value of 750.7 ± 0.13 μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretion and toxicity were also studied. Conclusion: This study has identified a range of potential hits against the α-glucosidase enzyme that may serve as antidiabetic agents after further investigations.

Original language	English
Pages (from-to)	1651-1668
Number of pages	18
Journal	Future Medicinal Chemistry
Volume	15
Issue number	18
DOIs	https://doi.org/10.4155/fmc-2023-0057
State	Published - 1 Sep 2023

Bibliographical note

Publisher Copyright:
© 2023 Newlands Press.

Keywords

competitive inhibitor
diabetes mellitus
in silico studies
triazine
α-glucosidase inhibitors

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4155/fmc-2023-0057

Cite this

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title = "Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies",

abstract = "Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35 ± 0.34 to 564.41 ± 0.91 μM, as the standard acarbose, IC50 value of 750.7 ± 0.13 μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretion and toxicity were also studied. Conclusion: This study has identified a range of potential hits against the α-glucosidase enzyme that may serve as antidiabetic agents after further investigations.",

keywords = "competitive inhibitor, diabetes mellitus, in silico studies, triazine, α-glucosidase inhibitors",

author = "Shahbaz Shamim and Khan, {Khalid Mohammed} and Muhammad Ali and Mohammad Mahdavi and Uzma Salar and Maryam Mohammadi-Khanaposhtani and Faramarzi, {Mohammad Ali} and Nisar Ullah and Muhammad Taha",

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year = "2023",

month = sep,

day = "1",

doi = "10.4155/fmc-2023-0057",

language = "English",

volume = "15",

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T1 - Diphenyl-substituted triazine derivatives

T2 - synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies

AU - Shamim, Shahbaz

AU - Khan, Khalid Mohammed

AU - Ali, Muhammad

AU - Mahdavi, Mohammad

AU - Salar, Uzma

AU - Mohammadi-Khanaposhtani, Maryam

AU - Faramarzi, Mohammad Ali

AU - Ullah, Nisar

AU - Taha, Muhammad

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35 ± 0.34 to 564.41 ± 0.91 μM, as the standard acarbose, IC50 value of 750.7 ± 0.13 μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretion and toxicity were also studied. Conclusion: This study has identified a range of potential hits against the α-glucosidase enzyme that may serve as antidiabetic agents after further investigations.

AB - Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to treat Type II DM. Methods: A new library of biphenyl-substituted triazines was synthesized and confirmed by various spectroscopic techniques. Results: All compounds showed potent α-glucosidase inhibitory activity, with IC50 values ranging from 35.35 ± 0.34 to 564.41 ± 0.91 μM, as the standard acarbose, IC50 value of 750.7 ± 0.13 μM. Our in silico study has predicted key interactions with the enzyme's active site. Drug-likeness and absorption, distribution, metabolism, excretion and toxicity were also studied. Conclusion: This study has identified a range of potential hits against the α-glucosidase enzyme that may serve as antidiabetic agents after further investigations.

KW - competitive inhibitor

KW - diabetes mellitus

KW - in silico studies

KW - triazine

KW - α-glucosidase inhibitors

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DO - 10.4155/fmc-2023-0057

M3 - Article

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AN - SCOPUS:85174640928

SN - 1756-8919

VL - 15

SP - 1651

EP - 1668

JO - Future Medicinal Chemistry

JF - Future Medicinal Chemistry

IS - 18

ER -

Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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