Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations

Abdalla M. Abulkibash; Salah M. Sultan; Abeer M. Al-Olyan; Sheikha M. Al-Ghannam

doi:10.1016/S0039-9140(03)00246-7

Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations

Abdalla M. Abulkibash^*, Salah M. Sultan, Abeer M. Al-Olyan, Sheikha M. Al-Ghannam

^*Corresponding author for this work

King Fahd University of Petroleum & Minerals

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm^-3. Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 μA cm ^-2 to these electrodes and using iron(III) solution of 0.097 mol dm^-3 as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.

Original language	English
Pages (from-to)	239-244
Number of pages	6
Journal	Talanta
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/S0039-9140(03)00246-7
State	Published - 17 Oct 2003

Keywords

Ciprofloxacin
Differential electrolytic potentiometry
Drug formulation
Iron(III)
Silver amalgam electrodes

ASJC Scopus subject areas

Analytical Chemistry

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10.1016/S0039-9140(03)00246-7

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title = "Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations",

abstract = "A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm-3. Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 μA cm -2 to these electrodes and using iron(III) solution of 0.097 mol dm-3 as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.",

keywords = "Ciprofloxacin, Differential electrolytic potentiometry, Drug formulation, Iron(III), Silver amalgam electrodes",

author = "Abulkibash, \{Abdalla M.\} and Sultan, \{Salah M.\} and Al-Olyan, \{Abeer M.\} and Al-Ghannam, \{Sheikha M.\}",

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doi = "10.1016/S0039-9140(03)00246-7",

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TY - JOUR

T1 - Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations

AU - Abulkibash, Abdalla M.

AU - Sultan, Salah M.

AU - Al-Olyan, Abeer M.

AU - Al-Ghannam, Sheikha M.

PY - 2003/10/17

Y1 - 2003/10/17

N2 - A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm-3. Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 μA cm -2 to these electrodes and using iron(III) solution of 0.097 mol dm-3 as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.

AB - A simple and rapid differential electrolytic potentiometric titration method for the determination of ciprofloxacin was developed. The work is based on the fast complexation reaction between iron(III) and ciprofloxacin in a ratio of 1:3, respectively, in sulfuric acid media of 0.09 mol dm-3. Among the electrodes tested silver amalgam electrodes were found to be a suitable indicating system. By applying a current density of 0.5 μA cm -2 to these electrodes and using iron(III) solution of 0.097 mol dm-3 as a titrant, normal titration curves were obtained. The method was successfully applied for the determination of ciprofloxacin in drug formulations as low as 4.0 ppm.

KW - Ciprofloxacin

KW - Differential electrolytic potentiometry

KW - Drug formulation

KW - Iron(III)

KW - Silver amalgam electrodes

UR - https://www.scopus.com/pages/publications/0142136666

U2 - 10.1016/S0039-9140(03)00246-7

DO - 10.1016/S0039-9140(03)00246-7

M3 - Article

AN - SCOPUS:0142136666

SN - 0039-9140

VL - 61

SP - 239

EP - 244

JO - Talanta

JF - Talanta

IS - 2

ER -

Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations

Abstract

Keywords

ASJC Scopus subject areas

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