TY - JOUR
T1 - Development and validation of a spectrophotometric method for the determination of entecavir in pure and tablet dosage form
AU - Shabbir, Hafiz Muhammad Nauman
AU - Hayat, Muhammad Munawar
AU - Ashraf, Muhammad
AU - Nasim, Faiz Ul Hassan
AU - Ahmad, Irshad
AU - Uzair, Muhammad
AU - Haque, Naheed
PY - 2012/12
Y1 - 2012/12
N2 - A direct spectrophotometric method for the determination of Entecavir is developed. Entecavir is a guanine analogue that is used in the treatment of hepatitis B. The absorbance of the pure drug was measured at wavelength 253 nm. The method was found linear from 2.5-40 μg mL-1 (r2, 0.999). The RSD was 1.1% and accuracy was 99%. The validation results and statistical data demonstrate that the method is reliable, simple, cost effective and reproducible and has an importance in quality assurance of Entecavir analysis.
AB - A direct spectrophotometric method for the determination of Entecavir is developed. Entecavir is a guanine analogue that is used in the treatment of hepatitis B. The absorbance of the pure drug was measured at wavelength 253 nm. The method was found linear from 2.5-40 μg mL-1 (r2, 0.999). The RSD was 1.1% and accuracy was 99%. The validation results and statistical data demonstrate that the method is reliable, simple, cost effective and reproducible and has an importance in quality assurance of Entecavir analysis.
KW - Entecavir
KW - Spectrophotometer
KW - Tablet dosage form
UR - https://www.scopus.com/pages/publications/84874467812
M3 - Article
AN - SCOPUS:84874467812
SN - 0253-5106
VL - 34
SP - 1605
EP - 1608
JO - Journal of the Chemical Society of Pakistan
JF - Journal of the Chemical Society of Pakistan
IS - 6
ER -
