Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry

Hoi Sim Nancy Lee; Chanbasha Basheer; Hian Kee Lee

doi:10.1016/j.chroma.2006.05.030

Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry

Hoi Sim Nancy Lee
, Chanbasha Basheer
, Hian Kee Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10%, n = 6), good linearity (r² ≥ 0.995) and limits of detection (LODs) in the range of 0.02-0.09 μg l^-1 (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15%, n = 3) and limits of detection (0.02-0.2 μg l^-1, S/N = 3) were obtained.

Original language	English
Pages (from-to)	91-96
Number of pages	6
Journal	Journal of Chromatography A
Volume	1124
Issue number	1-2
DOIs	https://doi.org/10.1016/j.chroma.2006.05.030
State	Published - 18 Aug 2006
Externally published	Yes

Bibliographical note

Funding Information:
The support from the Organic Synthesis Group of DSO National Laboratories is gratefully acknowledged. This work was funded by the Directorate of Research and Development, Defence Science and Technology Agency, Singapore. Nancy would like to thank DSO National Laboratories for co-sponsoring her graduate studies.

Keywords

Chemical warfare agents
Gas chromatography-mass spectrometry
Hollow fibre
Liquid-phase microextraction

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/j.chroma.2006.05.030

Cite this

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title = "Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry",

abstract = "A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10\%, n = 6), good linearity (r2 ≥ 0.995) and limits of detection (LODs) in the range of 0.02-0.09 μg l-1 (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15\%, n = 3) and limits of detection (0.02-0.2 μg l-1, S/N = 3) were obtained.",

keywords = "Chemical warfare agents, Gas chromatography-mass spectrometry, Hollow fibre, Liquid-phase microextraction",

author = "Lee, \{Hoi Sim Nancy\} and Chanbasha Basheer and Lee, \{Hian Kee\}",

note = "Funding Information: The support from the Organic Synthesis Group of DSO National Laboratories is gratefully acknowledged. This work was funded by the Directorate of Research and Development, Defence Science and Technology Agency, Singapore. Nancy would like to thank DSO National Laboratories for co-sponsoring her graduate studies.",

year = "2006",

month = aug,

day = "18",

doi = "10.1016/j.chroma.2006.05.030",

language = "English",

volume = "1124",

pages = "91--96",

journal = "Journal of Chromatography A",

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publisher = "Elsevier B.V.",

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}

Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry. / Lee, Hoi Sim Nancy; Basheer, Chanbasha; Lee, Hian Kee.
In: Journal of Chromatography A, Vol. 1124, No. 1-2, 18.08.2006, p. 91-96.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry

AU - Lee, Hoi Sim Nancy

AU - Basheer, Chanbasha

AU - Lee, Hian Kee

N1 - Funding Information: The support from the Organic Synthesis Group of DSO National Laboratories is gratefully acknowledged. This work was funded by the Directorate of Research and Development, Defence Science and Technology Agency, Singapore. Nancy would like to thank DSO National Laboratories for co-sponsoring her graduate studies.

PY - 2006/8/18

Y1 - 2006/8/18

N2 - A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10%, n = 6), good linearity (r2 ≥ 0.995) and limits of detection (LODs) in the range of 0.02-0.09 μg l-1 (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15%, n = 3) and limits of detection (0.02-0.2 μg l-1, S/N = 3) were obtained.

AB - A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10%, n = 6), good linearity (r2 ≥ 0.995) and limits of detection (LODs) in the range of 0.02-0.09 μg l-1 (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15%, n = 3) and limits of detection (0.02-0.2 μg l-1, S/N = 3) were obtained.

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Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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