Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode

Akilarasan Muthumariappan; Mani Govindasamy; Shen Ming Chen; Kogularasu Sakthivel; Veerappan Mani; Tse Wei Chen; Shanthi Selvaraj

doi:10.20964/2017.08.145

Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode

Akilarasan Muthumariappan, Mani Govindasamy, Shen Ming Chen^*, Kogularasu Sakthivel, Veerappan Mani, Tse Wei Chen, Shanthi Selvaraj

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn₃O₄ micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn₃O₄ MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn₃O₄ MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.

Original language	English
Pages (from-to)	7446-7456
Number of pages	11
Journal	International Journal of Electrochemical Science
Volume	12
Issue number	8
DOIs	https://doi.org/10.20964/2017.08.145
State	Published - 1 Aug 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Authors.

Keywords

Analytical Science
Biochemistry
Hybrid materials
Manganese oxide
Modified electrode
Multi-walled carbon nanotubes
Signal amplification

ASJC Scopus subject areas

Electrochemistry

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Muthumariappan, A., Govindasamy, M., Chen, S. M., Sakthivel, K., Mani, V., Chen, T. W., & Selvaraj, S. (2017). Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode. International Journal of Electrochemical Science, 12(8), 7446-7456. https://doi.org/10.20964/2017.08.145

Muthumariappan, Akilarasan ; Govindasamy, Mani ; Chen, Shen Ming et al. / Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode. In: International Journal of Electrochemical Science. 2017 ; Vol. 12, No. 8. pp. 7446-7456.

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title = "Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode",

abstract = "The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.",

keywords = "Analytical Science, Biochemistry, Hybrid materials, Manganese oxide, Modified electrode, Multi-walled carbon nanotubes, Signal amplification",

author = "Akilarasan Muthumariappan and Mani Govindasamy and Chen, \{Shen Ming\} and Kogularasu Sakthivel and Veerappan Mani and Chen, \{Tse Wei\} and Shanthi Selvaraj",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

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doi = "10.20964/2017.08.145",

language = "English",

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Muthumariappan, A, Govindasamy, M, Chen, SM, Sakthivel, K, Mani, V, Chen, TW & Selvaraj, S 2017, 'Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode', International Journal of Electrochemical Science, vol. 12, no. 8, pp. 7446-7456. https://doi.org/10.20964/2017.08.145

Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode. / Muthumariappan, Akilarasan; Govindasamy, Mani; Chen, Shen Ming et al.
In: International Journal of Electrochemical Science, Vol. 12, No. 8, 01.08.2017, p. 7446-7456.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Muthumariappan, Akilarasan

AU - Govindasamy, Mani

AU - Chen, Shen Ming

AU - Sakthivel, Kogularasu

AU - Mani, Veerappan

AU - Chen, Tse Wei

AU - Selvaraj, Shanthi

PY - 2017/8/1

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N2 - The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.

AB - The development of sensor for azathioprine (ATP) determination is extremely important as its excess level in blood imposes carcinogenic threats. A sensitive, selective, reproducible and durable azathioprine sensor was demonstrated using a nanocomposite composed of Mn3O4 micro cubes and multi-walled carbon nanotubes (MWCNTs/Mn3O4 MCs). The composite was prepared through a facile hydrothermal method and its morphology, elemental, impedance and electrochemical properties were studied. The MWCNTs/Mn3O4 MCs was modified on the screen-printed electrode, and the resulting modified electrode displayed excellent electrocatalytic ability towards ATP and the reduction peak current was related to the concentration of ATP. The working range was 0.045-2530 μM and the detection limit was 4.3 nM (± 2.53). The method was successfully applied to the determination of ATP in spiked samples of human blood serum and tablets.

KW - Analytical Science

KW - Biochemistry

KW - Hybrid materials

KW - Manganese oxide

KW - Modified electrode

KW - Multi-walled carbon nanotubes

KW - Signal amplification

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DO - 10.20964/2017.08.145

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SN - 1452-3981

VL - 12

SP - 7446

EP - 7456

JO - International Journal of Electrochemical Science

JF - International Journal of Electrochemical Science

IS - 8

ER -

Muthumariappan A, Govindasamy M, Chen SM, Sakthivel K, Mani V, Chen TW et al. Determination of Non-Steroidal Anti-Inflammatory Drug (NSAID) azathioprine in human blood serum and tablet samples using Multi-Walled Carbon Nanotubes (MWCNTs) decorated manganese oxide microcubes composite film modified electrode. International Journal of Electrochemical Science. 2017 Aug 1;12(8):7446-7456. doi: 10.20964/2017.08.145