Abstract
A Pyrex glass capillary (0.4 mm internal diameter) microreactor was developed and used for Suzuki coupling reactions. Capillary-microreactors are more attractive than photolithographic microfluidic devices in terms of simplicity, low cost and ease of handling. Compared with the conventional synthesis procedure, our approach of using a capillary-microreactor offers a convenient and highly efficient means to optimize reaction conditions and the performance of catalysts. The procedure exhibits good precision, reproducibility and high reaction yield for a range of reactants investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 7297-7300 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 45 |
| Issue number | 39 |
| DOIs | |
| State | Published - 20 Sep 2004 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors gratefully acknowledge the financial support the Agency for Science, Technology and Research of Singapore and the National University of Singapore.
Keywords
- Microfluidics
- Microreactors
- Reaction engineering
- Suzuki coupling
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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