Abstract
The present article reports the synthesis of polythiophene-titanium(IV) phosphate nanocomposite (PTh-TiP) by a simple in situ titanium(IV) phosphate assisted chemical polymerization of thiophene. The structure and formation of polymer and its nanocomposite was confirmed by FTIR, XRD, FE-SEM, TEM, and TGA techniques. UV-Visible, fluorescence, and circular dichroism spectrophotometry as well as viscometry and DNA melting studies were used to investigate the DNA binding of PTh and PTh-TiP with calf-thymus DNA. The anticancer activities of these materials against MCF-7 and MDA-MB- 231 cancer cells indicated both PTh and PTh-TiP are moderately active, with the latter being more active than the former.
| Original language | English |
|---|---|
| Pages (from-to) | 243-257 |
| Number of pages | 15 |
| Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Volume | 66 |
| Issue number | 5 |
| DOIs | |
| State | Published - 24 Mar 2017 |
Bibliographical note
Publisher Copyright:© 2017, Copyright © Taylor & Francis.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Cytotoxic activity
- DNA binding
- molecular docking
- polymer
- polymeric nanocomposite
- toxicity
ASJC Scopus subject areas
- Analytical Chemistry
- General Chemical Engineering
- Polymers and Plastics
Fingerprint
Dive into the research topics of 'Design, facile synthesis, molecular docking, DNA binding, and cytotoxic activity of polythiophene and polythiophene-titanium(IV) phosphate nanocomposite'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver