Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

N. Kurniasih; A. Supriadin; M. Fajar; R. Abdulah; D. Harneti; U. Supratman; M. N.A.B.M. Taib

doi:10.1088/1742-6596/1402/5/055037

Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

N. Kurniasih, A. Supriadin, M. Fajar, R. Abdulah, D. Harneti, U. Supratman, M. N.A.B.M. Taib

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

Previous phytochemical studies from the Aglaia genus reported the presence of terpenoid compound. This research describes the isolation and structure elucidation of sesquiterpend compound from the stembark of Aglaia simplicifolia. Dried stembark of A. simplicifolia extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol, respectively. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compound. The chemical structure of isolated compound was elucidated by IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The compound identified as senecrassidiol. This compound showed cytotoxicity activity against HeLa cervical cancer cells with IC₅₀ values of 2.18 μM.

Original language	English
Article number	055037
Journal	Journal of Physics: Conference Series
Volume	1402
Issue number	5
DOIs	https://doi.org/10.1088/1742-6596/1402/5/055037
State	Published - 16 Dec 2019
Externally published	Yes
Event	4th Annual Applied Science and Engineering Conference, AASEC 2019 - Bali, Indonesia Duration: 24 Apr 2019 → …

Bibliographical note

Publisher Copyright:
© Published under licence by IOP Publishing Ltd.

ASJC Scopus subject areas

General Physics and Astronomy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/1742-6596/1402/5/055037

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title = "Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)",

abstract = "Previous phytochemical studies from the Aglaia genus reported the presence of terpenoid compound. This research describes the isolation and structure elucidation of sesquiterpend compound from the stembark of Aglaia simplicifolia. Dried stembark of A. simplicifolia extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol, respectively. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compound. The chemical structure of isolated compound was elucidated by IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The compound identified as senecrassidiol. This compound showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 2.18 μM.",

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T1 - Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

AU - Kurniasih, N.

AU - Supriadin, A.

AU - Fajar, M.

AU - Abdulah, R.

AU - Harneti, D.

AU - Supratman, U.

AU - Taib, M. N.A.B.M.

PY - 2019/12/16

Y1 - 2019/12/16

N2 - Previous phytochemical studies from the Aglaia genus reported the presence of terpenoid compound. This research describes the isolation and structure elucidation of sesquiterpend compound from the stembark of Aglaia simplicifolia. Dried stembark of A. simplicifolia extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol, respectively. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compound. The chemical structure of isolated compound was elucidated by IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The compound identified as senecrassidiol. This compound showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 2.18 μM.

AB - Previous phytochemical studies from the Aglaia genus reported the presence of terpenoid compound. This research describes the isolation and structure elucidation of sesquiterpend compound from the stembark of Aglaia simplicifolia. Dried stembark of A. simplicifolia extracted with methanol and then partitioned with n-hexane, ethyl acetate, and n-butanol, respectively. The n-hexane extract then was separated and purified with chromatography techniques to obtain isolated compound. The chemical structure of isolated compound was elucidated by IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. The compound identified as senecrassidiol. This compound showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 2.18 μM.

UR - https://www.scopus.com/pages/publications/85077816699

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DO - 10.1088/1742-6596/1402/5/055037

M3 - Conference article

AN - SCOPUS:85077816699

SN - 1742-6588

VL - 1402

JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

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M1 - 055037

T2 - 4th Annual Applied Science and Engineering Conference, AASEC 2019

Y2 - 24 April 2019

ER -

Cytotoxic sesquterpenoid compound from the stembark of Aglaia simplicifolia (Meliaceae)

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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