@inproceedings{ef4f00c3496e42d69e9c4d7f55f9c78d,
title = "CyberRat probes: High-resolution biohybrid devices for probing the brain",
abstract = "Neuronal probes can be defined as biohybrid entities where the probes and nerve cells establish a close physical interaction for communicating in one or both directions. During the last decade neuronal probe technology has seen an exploded development. This paper presents newly developed chip-based CyberRat probes for enhanced signal transmission from nerve cells to chip or from chip to nerve cells with an emphasis on in-vivo interfacing, either in terms of signal-to-noise ratio or of spatiotemporal resolution. The oxide-insulated chips featuring large-scale and high-resolution arrays of stimulation and recording elements are a promising technology for high spatiotemporal resolution biohybrid devices, as recently demonstrated by recordings obtained from hippocampal slices and brain cortex in implanted animals. Finally, we report on SigMate, an in-house comprehensive automated tool for processing and analysis of acquired signals by such large scale biohybrid devices.",
keywords = "Neuronal probe, biohybrid devices, brain recording, brain stimulation, neuronal signal analysis",
author = "Stefano Vassanelli and Florian Felderer and Mufti Mahmud and Marta Maschietto and Stefano Girardi",
year = "2012",
doi = "10.1007/978-3-642-31525-1\_24",
language = "English",
isbn = "9783642315244",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
pages = "274--285",
booktitle = "Biomimetic and Biohybrid Systems - First International Conference, Living Machines 2012, Proceedings",
note = "1st International Conference on Biomimetic and Biohybrid Systems, Living Machines 2012 ; Conference date: 09-07-2012 Through 12-07-2012",
}