Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

Abdelkader Hassani, Siti Aslina Hussain, Mothanna Sadiq Al-Qubaisi, Mohamed Lakhder Belfar, Hakim Belkhalfa, Hamid Hammad Enezei, Hamid Zentou, Wisam Nabeel Ibrahim*, Abd Almonem Doolaanea*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.

Original languageEnglish
Pages (from-to)677-687
Number of pages11
JournalBiocell
Volume46
Issue number3
DOIs
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Centro Regional de Invest. Cientif. y Tecn.. All rights reserved.

Keywords

  • Antioxidants
  • Cancer cells
  • Curcumin
  • Gum arabic
  • Nanoparticles

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells'. Together they form a unique fingerprint.

Cite this