Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

Saeed Ahmad; Seerat-ur-Rehman; Tobias Rüffer; Tanzeel Khalid; Anvarhusein A. Isab; Abdul Rahman Al-Arfaj; Muhammad Saleem; Ejaz; Islam Ullah Khan; Muhammad Aziz Choudhary

doi:10.1007/s00706-016-1809-4

Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH₃)₂(dmtu)₂]Cl₂

Saeed Ahmad^*
, Seerat-ur-Rehman
, Tobias Rüffer
, Tanzeel Khalid
, Anvarhusein A. Isab
, Abdul Rahman Al-Arfaj
, Muhammad Saleem
, Ejaz
, Islam Ullah Khan
, Muhammad Aziz Choudhary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH₃)₂(dmtu)₂]Cl₂ (dmtu = N,N^’-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH₃)₂(dmtu)₂]²⁺ cation and two chloride ions. In trans-[Pt(NH₃)₂(dmtu)₂]²⁺, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The ¹H and ¹³C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	669-674
Number of pages	6
Journal	Monatshefte fur Chemie
Volume	148
Issue number	4
DOIs	https://doi.org/10.1007/s00706-016-1809-4
State	Published - 1 Apr 2017

Bibliographical note

Publisher Copyright:
© 2016, Springer-Verlag Wien.

Keywords

N,N′-Dimethylthiourea
Platinum(II) complexes
Transplatin
X-ray structure

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1007/s00706-016-1809-4

Cite this

@article{a6b12ff4bc004589949a1b81fa2cc4a8,

title = "Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2 ",

abstract = "Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N{\textquoteright}-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]",

keywords = "N,N′-Dimethylthiourea, Platinum(II) complexes, Transplatin, X-ray structure",

author = "Saeed Ahmad and Seerat-ur-Rehman and Tobias R{\"u}ffer and Tanzeel Khalid and Isab, \{Anvarhusein A.\} and Al-Arfaj, \{Abdul Rahman\} and Muhammad Saleem and Ejaz and Khan, \{Islam Ullah\} and Choudhary, \{Muhammad Aziz\}",

note = "Publisher Copyright: {\textcopyright} 2016, Springer-Verlag Wien.",

year = "2017",

month = apr,

day = "1",

doi = "10.1007/s00706-016-1809-4",

language = "English",

volume = "148",

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TY - JOUR

T1 - Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2

AU - Ahmad, Saeed

AU - Seerat-ur-Rehman,

AU - Rüffer, Tobias

AU - Khalid, Tanzeel

AU - Isab, Anvarhusein A.

AU - Al-Arfaj, Abdul Rahman

AU - Saleem, Muhammad

AU - Ejaz,

AU - Khan, Islam Ullah

AU - Choudhary, Muhammad Aziz

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N’-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N’-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]

KW - N,N′-Dimethylthiourea

KW - Platinum(II) complexes

KW - Transplatin

KW - X-ray structure

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U2 - 10.1007/s00706-016-1809-4

DO - 10.1007/s00706-016-1809-4

M3 - Article

AN - SCOPUS:84983391456

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