TY - JOUR
T1 - Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2
AU - Ahmad, Saeed
AU - Seerat-ur-Rehman,
AU - Rüffer, Tobias
AU - Khalid, Tanzeel
AU - Isab, Anvarhusein A.
AU - Al-Arfaj, Abdul Rahman
AU - Saleem, Muhammad
AU - Ejaz,
AU - Khan, Islam Ullah
AU - Choudhary, Muhammad Aziz
N1 - Publisher Copyright:
© 2016, Springer-Verlag Wien.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N’-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]
AB - Abstract: The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N’-dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). Graphical abstract: [Figure not available: see fulltext.]
KW - N,N′-Dimethylthiourea
KW - Platinum(II) complexes
KW - Transplatin
KW - X-ray structure
UR - https://www.scopus.com/pages/publications/84983391456
U2 - 10.1007/s00706-016-1809-4
DO - 10.1007/s00706-016-1809-4
M3 - Article
AN - SCOPUS:84983391456
SN - 0026-9247
VL - 148
SP - 669
EP - 674
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 4
ER -