Abstract
Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.
| Original language | English |
|---|---|
| Pages (from-to) | 46-59 |
| Number of pages | 14 |
| Journal | Heterocyclic Communications |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2020 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 Irfan et al., published by De Gruyter 2020.
Keywords
- anti-cancer
- anti-inflammatory
- anti-oxidant
- antimicrobial
- biological activities
- coumarin sulfonamide
ASJC Scopus subject areas
- Organic Chemistry
