Construction of perovskite structured ZnSnO₃ embedded graphene oxide nanosheets for in-situ electrochemical quantification of organoarsenic roxarsone

4-hydroxy-3-nitrophenylarsonic acid (HNPA) is an organoarsenic drug commonly known as roxarsone, which has been intensively used as a feed additive in poultry industries. However, the HNPA can easily degrade into highly toxic inorganic arsenic poisoning in biotic and abiotic nature, which threatens human health and the environment. Along with various conventional techniques, the electrochemical sensor based on nanomaterials has emerged as a potential tool for analyzing organoarsenic chemicals, owing to its ease of operation and accuracy. Herein, for the first time, we report the efficient and tremendously sensitive perovskite-structured ZnSnO₃@GO nanocomposites for the electrochemical analysis of HNPA. The as-prepared ZnSnO₃@GO nanocomposites with good chemical stability, excellent electron mobility, and larger specific area are beneficial to the HNPA reduction. In addition, the analytical performance of the developed sensor shows the minimized reduction potential of (−0.63 V vs Ag/AgCl) with an admirable linear range of 0.01–453.4 µM and a lower detection limit of 0.0043 µM toward HNPA detection. Finally, the real sample analysis of the developed sensor was quantified in the chicken and soil samples, which exhibits appreciable accuracy. The developed ZnSnO₃@GO/GCE provides a powerful tool for the rapid and sensitive detection of HNPA in actual samples.