Concentration profiles and breakthrough curves in non‐linear chromatography

The treatment of the non‐linear isotherm in chromatography by one of the authors [1] is extended to other cases of practical interest. The original paper dealt with the case of an initially thin zone resulting in a Poisson distribution the asymmetry of which is a function of the plate number and the non‐linearity constant. The present work shows that the same relations apply to initially thick zones and to the cases of washing and deposition leading to simple relations for breakthrough curves. For significantly non‐linear isotherms other quasi‐Gaussian distributions can give a better fit.