TY - JOUR
T1 - Complexation of captopril with gold(I) and its exchange reactions with thiomalate and cyanide
AU - Isab, Anvarhusein A.
AU - Ghazi, Ibrahim
AU - Al-Arfaj, Abdul Rahman
PY - 1993
Y1 - 1993
N2 - Captopril {Hcap, 1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline} with gold(I) forms a 1:1 crystalline complex [Au(cap)]. The exchange reactions of thiomalate and cyanide with [Au(cap)] have been studied using 13C NMR spectroscopy. It is found that [Au(cap)] forms a very high-molecular-weight polymer compared to gold(I) thiomalate. Thiomalate and CN- both bind to [Au(cap)], however, as expected, CN- binds more strongly. When 13CN- was added to [Au(cap)] solution, 13C NMR resonances due to [Au(cap) (13CN)]- (two isomers containing cis or trans cap) and [Au(13CN)2]- were observed. Evidence is presented which shows that the cis isomer of [Au(cap) (13CN)]- is more stable than the trans.
AB - Captopril {Hcap, 1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline} with gold(I) forms a 1:1 crystalline complex [Au(cap)]. The exchange reactions of thiomalate and cyanide with [Au(cap)] have been studied using 13C NMR spectroscopy. It is found that [Au(cap)] forms a very high-molecular-weight polymer compared to gold(I) thiomalate. Thiomalate and CN- both bind to [Au(cap)], however, as expected, CN- binds more strongly. When 13CN- was added to [Au(cap)] solution, 13C NMR resonances due to [Au(cap) (13CN)]- (two isomers containing cis or trans cap) and [Au(13CN)2]- were observed. Evidence is presented which shows that the cis isomer of [Au(cap) (13CN)]- is more stable than the trans.
UR - https://www.scopus.com/pages/publications/37049077316
U2 - 10.1039/DT9930000841
DO - 10.1039/DT9930000841
M3 - Article
AN - SCOPUS:37049077316
SN - 1472-7773
SP - 841
EP - 845
JO - Journal of the Chemical Society, Dalton Transactions
JF - Journal of the Chemical Society, Dalton Transactions
IS - 6
ER -