Comparison of mean serum prolactin levels between healthy and psoriatic patients

Sabahat Shehzadi*, Ghazala Butt, Wajieha Saeed, Huma Saleem, Anam Mehmood, Ijaz Hussain

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective The goals of this study were to evaluate the mean blood prolactin levels between healthy and psoriatic patients and to ascertain the prevalence of psoriasis in patients presenting to a teaching hospital in Punjab. Methods This study involved 153 patients of both genders aged between 18-70 years who presented at outpatient department of Dermatology, Mayo Hospital Lahore. 153 patients of both genders aged between 18-70 years were evaluated for psoriasis which was diagnosed clinically by the presence of red inflamed, sharply demarcated, indurated plaques, with silvery white scales over extensor surfaces and scalp for ≥6 months. 5ml of venous blood was sampled through venipuncture and was sent for serum prolactin level estimation. Mean serum prolactin level was compared between patients with and without psoriasis. A written informed consent was taken from each patient. Results The patients were 40.11±4.9 years old on average. The majority of the patients (n=103, 67.3%) were in the 18-44 age range. Male to female ratio was 2:1, with 102 (66.7%) men and 51 (33.3%) women among the patients. These individuals serum prolactin levels ranged from 5.6ng/ml to 15.9ng/ml, with an average of 8.9±2.3ng/ml. Six individuals (3.9%) had psoriasis, which was identified. The prevalence of psoriasis did not differ statistically significantly by gender (p-value=1.000) or by age (p-value=0.972). Patients with psoriasis had considerably higher mean serum prolactin levels than those without psoriasis (14.80±1.05 vs. 8.68±1.97 ng/ml; p-value 0.001). Patients with and without psoriasis were divided into several subgroups based on patient's age, with similar substantial differences in mean serum prolactin level being identified. Conclusion In the present study, 3.9% of patients presenting in dermatology outpatient department had psoriasis and these patients had significantly higher mean serum prolactin level compared to those without psoriasis which might be a potential therapeutic target and necessitates further studies in this regard to establish cause-effect relationship.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalJournal of Pakistan Association of Dermatologists
Issue number1
StatePublished - Jan 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Pakistan Association of Dermatologists. All rights reserved.


  • Keratinization
  • Psoriasis
  • Serum Prolactin

ASJC Scopus subject areas

  • Dermatology


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