Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery

Muhammad Farid-ul-Haq; Muhammad Amin; Muhammad Ajaz Hussain; Muhammad Sher; Taskin Aman Khan; Fahmeeda Kausar; Hatem M.A. Amin

doi:10.1080/1023666X.2020.1819085

Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery

Muhammad Farid-ul-Haq
, Muhammad Amin
, Muhammad Ajaz Hussain^*
, Muhammad Sher
, Taskin Aman Khan
, Fahmeeda Kausar
, Hatem M.A. Amin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS ¹³C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol⁻¹ for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release.

Original language	English
Pages (from-to)	529-538
Number of pages	10
Journal	International Journal of Polymer Analysis and Characterization
Volume	25
Issue number	7
DOIs	https://doi.org/10.1080/1023666X.2020.1819085
State	Published - 2 Oct 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

Artemisia vulgaris hydrogel
acetylation
drug release
isoconversional thermal analysis
solid-state NMR

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
Polymers and Plastics

Access to Document

10.1080/1023666X.2020.1819085

Cite this

Farid-ul-Haq, M., Amin, M., Hussain, M. A., Sher, M., Khan, T. A., Kausar, F., & Amin, H. M. A. (2020). Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery. International Journal of Polymer Analysis and Characterization, 25(7), 529-538. https://doi.org/10.1080/1023666X.2020.1819085

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title = "Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery",

abstract = "Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS 13C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol−1 for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release.",

keywords = "Artemisia vulgaris hydrogel, acetylation, drug release, isoconversional thermal analysis, solid-state NMR",

author = "Muhammad Farid-ul-Haq and Muhammad Amin and Hussain, \{Muhammad Ajaz\} and Muhammad Sher and Khan, \{Taskin Aman\} and Fahmeeda Kausar and Amin, \{Hatem M.A.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Taylor \& Francis Group, LLC.",

year = "2020",

month = oct,

day = "2",

doi = "10.1080/1023666X.2020.1819085",

language = "English",

volume = "25",

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Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery. / Farid-ul-Haq, Muhammad; Amin, Muhammad; Hussain, Muhammad Ajaz et al.
In: International Journal of Polymer Analysis and Characterization, Vol. 25, No. 7, 02.10.2020, p. 529-538.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery

AU - Farid-ul-Haq, Muhammad

AU - Amin, Muhammad

AU - Hussain, Muhammad Ajaz

AU - Sher, Muhammad

AU - Khan, Taskin Aman

AU - Kausar, Fahmeeda

AU - Amin, Hatem M.A.

PY - 2020/10/2

Y1 - 2020/10/2

N2 - Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS 13C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol−1 for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release.

AB - Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS 13C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol−1 for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release.

KW - Artemisia vulgaris hydrogel

KW - acetylation

KW - drug release

KW - isoconversional thermal analysis

KW - solid-state NMR

UR - https://www.scopus.com/pages/publications/85092672988

U2 - 10.1080/1023666X.2020.1819085

DO - 10.1080/1023666X.2020.1819085

M3 - Article

AN - SCOPUS:85092672988

SN - 1023-666X

VL - 25

SP - 529

EP - 538

JO - International Journal of Polymer Analysis and Characterization

JF - International Journal of Polymer Analysis and Characterization

IS - 7

ER -

Comparative isoconversional thermal analysis of Artemisia vulgaris hydrogel and its acetates; a potential matrix for sustained drug delivery

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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