Comparative folate metabolism in humans and malaria parasites (part I): Pointers for malaria treatment from cancer chemotherapy

Alexis Nzila; Steve A. Ward; Kevin Marsh; Paul F.G. Sims; John E. Hyde

doi:10.1016/j.pt.2005.04.002

Comparative folate metabolism in humans and malaria parasites (part I): Pointers for malaria treatment from cancer chemotherapy

Alexis Nzila^*
, Steve A. Ward
, Kevin Marsh
, Paul F.G. Sims
, John E. Hyde

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we focus on folate enzymes used clinically as anticancer drug targets, in addition to those that have potential to be used as drug targets, for which there are inhibitors at various stages of development. We discuss how this information could lead to the identification of new targets in malaria parasites.

Original language	English
Pages (from-to)	292-298
Number of pages	7
Journal	Trends in Parasitology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.pt.2005.04.002
State	Published - Jun 2005
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Wellcome Trust (grants 056769, 056845, 062372, 067201 and 073896), the Biotechnology and Biological Sciences Research Council (grant 36/JE616379) and the NIH (Fogarty International grant TW 01186). A.N. and K.M. thank the Wellcome Trust for personal support. S.A.W. thanks the Wellcome Trust for institutional support. We apologize to those authors whose work was not cited because of space limitations.

ASJC Scopus subject areas

Parasitology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2005.04.002

Cite this

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title = "Comparative folate metabolism in humans and malaria parasites (part I): Pointers for malaria treatment from cancer chemotherapy",

abstract = "New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we focus on folate enzymes used clinically as anticancer drug targets, in addition to those that have potential to be used as drug targets, for which there are inhibitors at various stages of development. We discuss how this information could lead to the identification of new targets in malaria parasites.",

author = "Alexis Nzila and Ward, \{Steve A.\} and Kevin Marsh and Sims, \{Paul F.G.\} and Hyde, \{John E.\}",

note = "Funding Information: This work was supported by the Wellcome Trust (grants 056769, 056845, 062372, 067201 and 073896), the Biotechnology and Biological Sciences Research Council (grant 36/JE616379) and the NIH (Fogarty International grant TW 01186). A.N. and K.M. thank the Wellcome Trust for personal support. S.A.W. thanks the Wellcome Trust for institutional support. We apologize to those authors whose work was not cited because of space limitations. ",

year = "2005",

month = jun,

doi = "10.1016/j.pt.2005.04.002",

language = "English",

volume = "21",

pages = "292--298",

journal = "Trends in Parasitology",

issn = "1471-4922",

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T1 - Comparative folate metabolism in humans and malaria parasites (part I)

T2 - Pointers for malaria treatment from cancer chemotherapy

AU - Nzila, Alexis

AU - Ward, Steve A.

AU - Marsh, Kevin

AU - Sims, Paul F.G.

AU - Hyde, John E.

N1 - Funding Information: This work was supported by the Wellcome Trust (grants 056769, 056845, 062372, 067201 and 073896), the Biotechnology and Biological Sciences Research Council (grant 36/JE616379) and the NIH (Fogarty International grant TW 01186). A.N. and K.M. thank the Wellcome Trust for personal support. S.A.W. thanks the Wellcome Trust for institutional support. We apologize to those authors whose work was not cited because of space limitations.

PY - 2005/6

Y1 - 2005/6

N2 - New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we focus on folate enzymes used clinically as anticancer drug targets, in addition to those that have potential to be used as drug targets, for which there are inhibitors at various stages of development. We discuss how this information could lead to the identification of new targets in malaria parasites.

AB - New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we focus on folate enzymes used clinically as anticancer drug targets, in addition to those that have potential to be used as drug targets, for which there are inhibitors at various stages of development. We discuss how this information could lead to the identification of new targets in malaria parasites.

UR - https://www.scopus.com/pages/publications/19444371029

U2 - 10.1016/j.pt.2005.04.002

DO - 10.1016/j.pt.2005.04.002

M3 - Review article

C2 - 15922251

AN - SCOPUS:19444371029

SN - 1471-4922

VL - 21

SP - 292

EP - 298

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 6

ER -

Comparative folate metabolism in humans and malaria parasites (part I): Pointers for malaria treatment from cancer chemotherapy

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this