Abstract
Commercially available therapeutic proteins are formulated as both liquid and lyophilized products. The most common buffer utilized is phosphate, followed by histidine, citrate, acetate, tris, and others. Excipients that are most frequently utilized are sodium chloride, sucrose, and the non-ionic detergents polysorbate 20 and 80. The most common containers utilized are vials followed by pre-filled syringes. These marketed therapeutic protein drug products formulations may be used as a reference point during the development of future products.
| Original language | English |
|---|---|
| Title of host publication | Therapeutic Protein Drug Products |
| Subtitle of host publication | Practical Approaches to formulation in the Laboratory, Manufacturing, and the Clinic |
| Publisher | Elsevier Ltd. |
| Pages | 1-11 |
| Number of pages | 11 |
| ISBN (Print) | 9781907568183 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
Keywords
- Administration
- Buffer
- Commercial
- Container
- Excipients
- Formulation
- Liquid
- Lyophilized
- Protein
- Salt
- Sugar
- Therapeutic
ASJC Scopus subject areas
- General Dentistry
- General Medicine