Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy

Sk Abdus Samim; Bivas Chandra Roy; Sourav Nayak; Sabuj Kundu

doi:10.1021/acs.joc.0c01307

Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy

Sk Abdus Samim, Bivas Chandra Roy, Sourav Nayak, Sabuj Kundu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alcohol-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

Original language	English
Pages (from-to)	11359-11367
Number of pages	9
Journal	Journal of Organic Chemistry
Volume	85
Issue number	17
DOIs	https://doi.org/10.1021/acs.joc.0c01307
State	Published - 4 Sep 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 American Chemical Society.

ASJC Scopus subject areas

Organic Chemistry

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10.1021/acs.joc.0c01307

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title = "Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy",

abstract = "A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alcohol-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.",

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doi = "10.1021/acs.joc.0c01307",

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AU - Roy, Bivas Chandra

AU - Nayak, Sourav

AU - Kundu, Sabuj

PY - 2020/9/4

Y1 - 2020/9/4

N2 - A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alcohol-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

AB - A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alcohol-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

UR - https://www.scopus.com/pages/publications/85092194309

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M3 - Article

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ER -

Cobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy

Abstract

Bibliographical note

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