TY - JOUR
T1 - Characterization of polymeric gold(I)-captopril complex using viscosity and various spectroscopic techniques
AU - Akhtar, Muhammad N.
AU - Isab, Anvarhusein A.
AU - Wazeer, Mohammad I.M.
PY - 1996/10
Y1 - 1996/10
N2 - The characterization of polymeric gold(I)-captopril (Aucap)(n) is carried out using viscosity, electronic, mass, and 13C, 15N NMR spectroscopy. From viscosity measurements, it is observed that the degree of association in (Aucap)(n) is much higher than in (Autm)(n). The (Aucap)(n) was further polymerized in the presence of SCN- and SeCN- ions; however, the CN- ion caused the breakdown of the polymer. After a few hours of the addition of SeCN- to (Aucap)(n) solution, SeCN- underwent decomposition to produce CN- and 'Se' metal which caused dissociation of the polymer. The mass spectroscopic results showed two characteristic routes of fragmentation for (Aucap)(n). Electronic spectroscopy indicated the generation of [Au(CN)2]- at a CN-:(Aucap)(n) ratio ≤ 1, whereas 13C, 15N NMR spectroscopic studies have indicated the detection of [Au(CN)2]even at a 1:12 ratio of CN-:(Aucap)(n). The 13C NMR is found to be sensitive to the configuration of the penultimate captopril moiety.
AB - The characterization of polymeric gold(I)-captopril (Aucap)(n) is carried out using viscosity, electronic, mass, and 13C, 15N NMR spectroscopy. From viscosity measurements, it is observed that the degree of association in (Aucap)(n) is much higher than in (Autm)(n). The (Aucap)(n) was further polymerized in the presence of SCN- and SeCN- ions; however, the CN- ion caused the breakdown of the polymer. After a few hours of the addition of SeCN- to (Aucap)(n) solution, SeCN- underwent decomposition to produce CN- and 'Se' metal which caused dissociation of the polymer. The mass spectroscopic results showed two characteristic routes of fragmentation for (Aucap)(n). Electronic spectroscopy indicated the generation of [Au(CN)2]- at a CN-:(Aucap)(n) ratio ≤ 1, whereas 13C, 15N NMR spectroscopic studies have indicated the detection of [Au(CN)2]even at a 1:12 ratio of CN-:(Aucap)(n). The 13C NMR is found to be sensitive to the configuration of the penultimate captopril moiety.
UR - https://www.scopus.com/pages/publications/0030272529
U2 - 10.1016/0162-0134(95)00242-1
DO - 10.1016/0162-0134(95)00242-1
M3 - Article
AN - SCOPUS:0030272529
SN - 0162-0134
VL - 64
SP - 37
EP - 53
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 1
ER -