Cell specific targeting of multifunctional γ-Fe2O 3 nanoparticles through surface binding of dsDNA

Wolfgang Tremel; Mohammed Ibrahim Shukoor; Filipe Natalio; Muhammad Nawaz Tahir; Werner E.G. Miiller; Heinz Christoph Schröder

Cell specific targeting of multifunctional γ-Fe₂O ₃ nanoparticles through surface binding of dsDNA

Wolfgang Tremel^*
, Mohammed Ibrahim Shukoor
, Filipe Natalio
, Muhammad Nawaz Tahir
, Werner E.G. Miiller
, Heinz Christoph Schröder

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

Abstract

The immobilization of polyinosinic-polycytidylic acid [poly(I:C)] on γ-Fe₂O₃ nanoparticles via the phosphor-amidate route using a multifunctional polymer is reported. The dsRNA coupled nanoparticles were used to visualize the Toll-like (TLR3) receptors at the cell surface. The presence of TLR3 was demonstrated independently in the Caki-1 cell line by RT-PCR and immunostaining techniques.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Materials Research Society Symposium - Proceedings
Volume	1032
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

@article{48d5070d328d478dbcfa2f3c818b24b4,

title = "Cell specific targeting of multifunctional γ-Fe2O 3 nanoparticles through surface binding of dsDNA",

abstract = "The immobilization of polyinosinic-polycytidylic acid [poly(I:C)] on γ-Fe2O3 nanoparticles via the phosphor-amidate route using a multifunctional polymer is reported. The dsRNA coupled nanoparticles were used to visualize the Toll-like (TLR3) receptors at the cell surface. The presence of TLR3 was demonstrated independently in the Caki-1 cell line by RT-PCR and immunostaining techniques.",

author = "Wolfgang Tremel and Shukoor, \{Mohammed Ibrahim\} and Filipe Natalio and Tahir, \{Muhammad Nawaz\} and Miiller, \{Werner E.G.\} and Schr{\"o}der, \{Heinz Christoph\}",

year = "2008",

language = "English",

volume = "1032",

pages = "61--65",

journal = "Materials Research Society Symposium - Proceedings",

issn = "0272-9172",

publisher = "Materials Research Society",

}

TY - JOUR

T1 - Cell specific targeting of multifunctional γ-Fe2O 3 nanoparticles through surface binding of dsDNA

AU - Tremel, Wolfgang

AU - Shukoor, Mohammed Ibrahim

AU - Natalio, Filipe

AU - Tahir, Muhammad Nawaz

AU - Miiller, Werner E.G.

AU - Schröder, Heinz Christoph

PY - 2008

Y1 - 2008

N2 - The immobilization of polyinosinic-polycytidylic acid [poly(I:C)] on γ-Fe2O3 nanoparticles via the phosphor-amidate route using a multifunctional polymer is reported. The dsRNA coupled nanoparticles were used to visualize the Toll-like (TLR3) receptors at the cell surface. The presence of TLR3 was demonstrated independently in the Caki-1 cell line by RT-PCR and immunostaining techniques.

AB - The immobilization of polyinosinic-polycytidylic acid [poly(I:C)] on γ-Fe2O3 nanoparticles via the phosphor-amidate route using a multifunctional polymer is reported. The dsRNA coupled nanoparticles were used to visualize the Toll-like (TLR3) receptors at the cell surface. The presence of TLR3 was demonstrated independently in the Caki-1 cell line by RT-PCR and immunostaining techniques.

UR - https://www.scopus.com/pages/publications/67649183268

M3 - Conference article

AN - SCOPUS:67649183268

SN - 0272-9172

VL - 1032

SP - 61

EP - 65

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

ER -

Cell specific targeting of multifunctional γ-Fe2O 3 nanoparticles through surface binding of dsDNA

Abstract

ASJC Scopus subject areas

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Cite this

Cell specific targeting of multifunctional γ-Fe₂O ₃ nanoparticles through surface binding of dsDNA